锡兰刺山柑叶的镇痛和解热作用。

Analgesic and antipyretic effects of Capparis zeylanica leaves.

作者信息

Ghule B V, Murugananthan G, Yeole P G

机构信息

Institute of Pharmaceutical Education and Research, Borgaon, Wardha, MS, India.

出版信息

Fitoterapia. 2007 Jul;78(5):365-9. doi: 10.1016/j.fitote.2007.02.003. Epub 2007 Apr 11.

DOI:10.1016/j.fitote.2007.02.003

PMID:17512136

Abstract

The ethanol and water extracts of Capparis zeylanica leaves showed dose-dependent and significant (P<0.05) increases in pain threshold in tail-immersion test. Moreover, both the extracts (100-200 mg/kg) exhibited a dose-dependent inhibition of writhing and also showed a significant (P<0.001) inhibition of both phases of the formalin pain test. The water extract (200 mg/kg) significantly (P<0.01) reversed yeast-induced fever. Preliminary phytochemical screening of the extracts showed the presence of alkaloids, flavonoids, saponins glycosides, terpenoids, tannins, proteins and carbohydrates.

摘要

锡兰刺山柑叶的乙醇提取物和水提取物在尾部浸没法试验中显示出剂量依赖性且显著（P<0.05）的痛阈升高。此外，两种提取物（100 - 200 mg/kg）均表现出剂量依赖性的扭体抑制作用，并且在福尔马林疼痛试验的两个阶段均显示出显著（P<0.001）的抑制作用。水提取物（200 mg/kg）显著（P<0.01）逆转了酵母诱导的发热。对提取物的初步植物化学筛选表明存在生物碱、黄酮类化合物、皂苷糖苷、萜类化合物、单宁、蛋白质和碳水化合物。