一种来自紫金牛的具有对HIV-1和HIV-2核糖核酸酶H抑制活性的二聚内酯。
A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.
作者信息
Dat Nguyen Tien, Bae KiHwan, Wamiru Antony, McMahon James B, Le Grice Stuart F J, Bona Marion, Beutler John A, Kim Young Ho
机构信息
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
出版信息
J Nat Prod. 2007 May;70(5):839-41. doi: 10.1021/np060359m. Epub 2007 Mar 31.
A new dimeric lactone, ardimerin digallate (1), was isolated from the whole plants of Ardisia japonica, along with six known constituents. The structure of 1 was established on the basis of spectroscopic analysis including 1D- and 2D-NMR techniques. Compound 1 inhibited HIV-1 and HIV-2 RNase H in vitro with IC50 values of 1.5 and 1.1 microM, respectively.
从紫金牛全草中分离得到一种新的二聚内酯——杨梅苷二没食子酸酯（1），以及六种已知成分。通过包括一维和二维核磁共振技术在内的光谱分析确定了1的结构。化合物1在体外对HIV-1和HIV-2核糖核酸酶H具有抑制作用，IC50值分别为1.5和1.1微摩尔。
Zotero 插件