柳叶五味子中具有抗HIV-1活性的三萜类化合物。

Triterpenoids from Schisandra lancifolia with anti-HIV-1 activity.

作者信息

Xiao Wei-Lie, Tian Ren-Rong, Pu Jian-Xin, Li Xian, Wu Li, Lu Yang, Li Sheng-Hong, Li Rong-Tao, Zheng Yong-Tang, Zheng Qi-Tai, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.

出版信息

J Nat Prod. 2006 Feb;69(2):277-9. doi: 10.1021/np0503303.

DOI:10.1021/np0503303

PMID:16499331

Abstract

A new trinorcycloartane triterpenoid, lancifodilactone H (1), and a new A ring-secocycloartane triterpenoid, lancifoic acid A (2), together with a known compound, nigranoic acid (3), were isolated from the leaves and stems of Schisandra lancifolia. Their structures were elucidated by spectroscopic data analysis. Compound 1 features a biosynthetically modified seven-membered lactone ring, which was confirmed by single-crystal X-ray diffraction. Compounds 1-3 exhibited weak anti-HIV-1 activity in vitro.

摘要

从柳叶五味子的叶和茎中分离出一种新的三降环阿尔廷烷三萜类化合物披针叶内酯H（1）、一种新的A环开环环阿尔廷烷三萜类化合物披针叶酸A（2）以及一种已知化合物黑麦草酸（3）。通过光谱数据分析阐明了它们的结构。化合物1具有一个经生物合成修饰的七元内酯环，单晶X射线衍射证实了这一点。化合物1 - 3在体外表现出较弱的抗HIV - 1活性。