Sun A, Chia J S, Wang J T, Chiang C P
School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
Clin Exp Dermatol. 2007 May;32(3):308-10. doi: 10.1111/j.1365-2230.2006.02343.x.
In this study, we measured the baseline serum levels of tumour necrosis factor (TNF)-alpha in 158 patients with oral lichen planus (OLP) and in 54 normal control subjects. In total, 60 patients with erosive OLP (EOLP) with relatively high TNF-alpha levels were treated with levamisole and the serum TNF-alpha levels measured after treatment. We found that the mean +/- SD serum level of TNF-alpha in patients with either type of EOLP (12.0 +/- 1.7 pg/mL, P<0.005), major EOLP (15.5 +/- 4.4 pg/mL, P<0.001), minor EOLP (11.1 +/- 1.8 pg/mL, P<0.01), or nonerosive OLP (6.1 +/- 1.7 pg/mL, P<0.05) was significantly higher than that (3.8 +/- 0.2 pg/mL) of normal control subjects. Treatment with levamisole for a period of 0.5-7.5 months significantly reduced the mean serum TNF-alpha level from 22.6 +/- 3.4 pg/mL to 6.2 +/- 0.8 pg/mL (P<0.001) in 60 patients with EOLP. We conclude that levamisole can reduce high serum TNF-alpha levels to normal in patients with EOLP.
在本研究中，我们检测了158例口腔扁平苔藓（OLP）患者和54例正常对照者的基线血清肿瘤坏死因子（TNF）-α水平。共有60例TNF-α水平相对较高的糜烂型OLP（EOLP）患者接受了左旋咪唑治疗，并在治疗后检测血清TNF-α水平。我们发现，无论是哪种类型的EOLP患者（12.0±1.7 pg/mL，P<0.005）、重度EOLP患者（15.5±4.4 pg/mL，P<0.001）、轻度EOLP患者（11.1±1.8 pg/mL，P<0.01）或非糜烂型OLP患者（6.1±1.7 pg/mL，P<0.05），其血清TNF-α的平均±标准差水平均显著高于正常对照者（3.8±0.2 pg/mL）。对60例EOLP患者进行为期0.5 - 7.5个月的左旋咪唑治疗后，其血清TNF-α平均水平从22.6±3.4 pg/mL显著降至6.2±0.8 pg/mL（P<0.001）。我们得出结论，左旋咪唑可使EOLP患者升高的血清TNF-α水平降至正常。
