Graduate Institute of Clinical Dentistry, National Taiwan University, Taipei, Taiwan.
J Formos Med Assoc. 2011 Mar;110(3):169-74. doi: 10.1016/S0929-6646(11)60027-2.
BACKGROUND/PURPOSE: Several types of serum autoantibodies including anti-thyroglobulin (TGA) and anti-thyroid microsomal autoantibody (TMA) were detected in patients with oral lichen planus (OLP). This study evaluated whether Chinese OLP patients had significantly higher frequencies of serum TGA and TMA than healthy control subjects, and whether levamisole treatment could modulate serum TGA and TMA levels in Chinese OLP patients.
This study used a semi-quantitative microtiter particle agglutination test to measure the baseline serum levels of TGA and TMA in a group of 278 Chinese OLP patients and 53 healthy control subjects. Forty-one TGA-positive and 48 TMA-positive OLP patients were treated with levamisole for a complete period of 1 year, and their serum TGA and TMA levels were measured after treatment.
We found that the frequencies of serum TGA and TMA in patients with OLP (21.6% and 24.5%, respectively), erosive OLP (21.8% and 24.5%, respectively), or non-erosive OLP (19.0% and 23.8%, respectively) were significantly higher than those (1.9% and 1.9%, respectively) in healthy control subjects. After 1 year of levamisole treatment, the serum TGA and TMA titers decreased partially or became undetectable in 36 (88%) TGA-positive and 46 (96%) TMA-positive OLP patients. At least 9 months or 3 months of levamisole treatment were needed to reduce the mean serum TGA or TMA titer to a significantly lower level in OLP patients, respectively.
Significantly higher frequencies of serum TGA and TMA were found in Chinese OLP patients than in healthy control subjects. After 1 year of levamisole treatment, serum TGA and TMA levels were reduced partially or became undetectable in approximately 88% of TGA-positive and 96% of TMA-positive OLP patients.
背景/目的：几种类型的血清自身抗体，包括抗甲状腺球蛋白（TGA）和抗甲状腺微粒体自身抗体（TMA），在口腔扁平苔藓（OLP）患者中被检测到。本研究评估了中国 OLP 患者的血清 TGA 和 TMA 频率是否明显高于健康对照组，以及左旋咪唑治疗是否能调节中国 OLP 患者的血清 TGA 和 TMA 水平。
本研究使用半定量微粒凝集试验测量了一组 278 例中国 OLP 患者和 53 例健康对照组的基线血清 TGA 和 TMA 水平。41 例 TGA 阳性和 48 例 TMA 阳性 OLP 患者接受左旋咪唑治疗，为期 1 年，治疗后测量其血清 TGA 和 TMA 水平。
我们发现，OLP 患者（分别为 21.6%和 24.5%）、糜烂性 OLP 患者（分别为 21.8%和 24.5%）或非糜烂性 OLP 患者（分别为 19.0%和 23.8%）的血清 TGA 和 TMA 频率明显高于健康对照组（分别为 1.9%和 1.9%）。经过 1 年的左旋咪唑治疗，36 例（88%）TGA 阳性和 46 例（96%）TMA 阳性 OLP 患者的血清 TGA 和 TMA 滴度部分降低或变得不可检测。OLP 患者至少需要 9 个月或 3 个月的左旋咪唑治疗，才能使平均血清 TGA 或 TMA 滴度显著降低。
中国 OLP 患者的血清 TGA 和 TMA 频率明显高于健康对照组。经过 1 年的左旋咪唑治疗，约 88%的 TGA 阳性和 96%的 TMA 阳性 OLP 患者的血清 TGA 和 TMA 水平部分降低或变得不可检测。
