Edmondson H A, Henderson B, Benton B
N Engl J Med. 1976 Feb 26;294(9):470-2. doi: 10.1056/NEJM197602262940904.
During the past six years an increasing number of liver-cell adenomas in women were diagnosed, and we undertook a study of possible etiologic factors, including use of oral contraceptives, in 42 women. There was a significant difference between cases and matched controls in mean months of oral-contraceptive use: 73.4 as compared to 36.2 (P less than 0.001). The women with adenomas took mestranol-containing pills much more commonly than the controls (P less than 0.0001). Hemorrhage into the tumor was often associated with the onset of menstruation in women taking oral contraceptives. Long-term use of oral contraceptives, especially those containing a high total dose of steroids or mestranol as the synthetic estrogen, should be balanced against risks of side effects of the drugs.
在过去六年中，诊断出的女性肝细胞腺瘤数量不断增加，我们对42名女性进行了一项关于可能病因的研究，包括口服避孕药的使用情况。病例组和匹配对照组在口服避孕药的平均使用月数上存在显著差异：分别为73.4个月和36.2个月（P<0.001）。患有腺瘤的女性服用含炔雌醇的药丸比对照组更为常见（P<0.0001）。服用口服避孕药的女性，肿瘤内出血常与月经来潮有关。长期使用口服避孕药，尤其是那些含有高总剂量类固醇或炔雌醇作为合成雌激素的避孕药，应权衡药物副作用的风险。
