Tang Xiangdong, Yang Linghui, Sanford Larry D
Sleep Research Laboratory, Department of Pathology and Anatomy, Eastern Virginia Medical School, P.O. Box 1980, Norfolk, VA 23501, USA.
Behav Brain Res. 2007 Jun 4;180(1):62-8. doi: 10.1016/j.bbr.2007.02.022. Epub 2007 Feb 27.
We examined individual differences in sleep and motor activity across 2 consecutive days in rats. EEG and motor activity were recorded via telemetry in Wistar rats (n=29) for 48h under well-habituated conditions. Rats were grouped based on sleep amounts and stability across days (short [SS, n=7], intermediate [IS, n=15] and long [LS, n=7] sleep) and comparisons were conducted to determine group differences for measures of sleep and motor activity. We found that correlations across recording days were significant for all selected sleep measures and motor activity counts. Rankings for 24h total sleep time and non-rapid eye movement sleep (NREM) were SS<IS<LS rats whereas amounts of rapid eye movement sleep did not differ among groups. Further analyses of NREM episode parameters found significant differences in mean episode length (SS<IS<LS) but not in the number of episodes. Total and average motor activity counts (per waking min) were greater (32-38%) in SS compared to LS rats on both recording days. The results indicate that individual differences in sleep and motor activity in Wistar rats are stable across days. Differences between SS and LS rats have parallels to those reported for short and long sleep humans.
我们研究了大鼠连续两天睡眠和运动活动的个体差异。在适应良好的条件下，通过遥测技术对29只Wistar大鼠的脑电图（EEG）和运动活动进行了48小时的记录。根据大鼠的睡眠量和跨日稳定性进行分组（短睡眠组[SS，n = 7]、中等睡眠组[IS，n = 15]和长睡眠组[LS，n = 7]），并进行比较以确定睡眠和运动活动测量指标的组间差异。我们发现，所有选定的睡眠指标和运动活动计数在记录日之间的相关性均显著。24小时总睡眠时间和非快速眼动睡眠（NREM）的排名为SS组<IS组<LS组大鼠，而快速眼动睡眠量在各组之间没有差异。对NREM睡眠片段参数的进一步分析发现，平均片段长度存在显著差异（SS组<IS组<LS组），但片段数量没有差异。在两个记录日，SS组大鼠的总运动活动计数和平均运动活动计数（每清醒分钟）均比LS组大鼠高（32 - 38%）。结果表明，Wistar大鼠睡眠和运动活动的个体差异在不同日期是稳定的。SS组和LS组大鼠之间的差异与短睡眠和长睡眠人类的差异相似。
