Das Chandi Prasad, Prabhakar Sudesh, Truong Daniel
Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Parkinsonism Relat Disord. 2007 Oct;13(7):421-4. doi: 10.1016/j.parkreldis.2007.01.009. Epub 2007 Mar 30.
We profiled 141 consecutive patients of writer's cramp (WC). Simple WC (n=108) had a mean (SD) disease duration of 3.65 (2.7) years and a severity score of 2.8 (0.91) by Burke-Fahn-Marden (BFM) scale (handwriting score: 0-4 ), whereas complex WC (n=33) had a disease duration of 5.8 (2.81) years and severity score of 3.6 (0.52). Compared with focal WC, generalized WC cases had longer disease duration, severer disability, and were older. Mirror dystonia was seen in 65 patients (46.1%). Co-existent Meige's syndrome (n=4) and cervical dystonia (n=6) were seen. Some patients had abnormal posturing of the neck (n=5) and of the oromandibular region (n=3) only while writing. Those receiving botulinum toxin fared significantly better than those on oral therapy, at 1 month post treatment.
我们对141例连续性书写痉挛（WC）患者进行了分析。单纯性WC（n = 108）的平均（标准差）病程为3.65（2.7）年，根据伯克 - 法恩 - 马尔登（BFM）量表（书写评分：0 - 4），严重程度评分为2.8（0.91），而复杂性WC（n = 33）的病程为5.8（2.81）年，严重程度评分为3.6（0.52）。与局限性WC相比，全身性WC病例病程更长、残疾更严重且年龄更大。65例患者（46.1%）出现镜像性肌张力障碍。观察到共存的梅杰综合征（n = 4）和颈部肌张力障碍（n = 6）。一些患者仅在书写时出现颈部（n = 5）和口下颌区域（n = 3）的异常姿势。治疗1个月后，接受肉毒杆菌毒素治疗的患者比接受口服治疗的患者情况明显更好。
