免疫接种能降低婴儿猝死综合征的风险吗？一项荟萃分析。
Do immunisations reduce the risk for SIDS? A meta-analysis.
作者信息
Vennemann M M T, Höffgen M, Bajanowski T, Hense H-W, Mitchell E A
机构信息
Institute of Legal Medicine, University of Münster, Roentgenstrasse 23, 48129 Münster, Germany.
出版信息
Vaccine. 2007 Jun 21;25(26):4875-9. doi: 10.1016/j.vaccine.2007.02.077. Epub 2007 Mar 16.
BACKGROUND
There are claims that immunisations cause sudden infant death syndrome (SIDS), but some studies have found either no association or that they are associated with a reduced risk of SIDS.
AIMS
To conduct a meta-analysis examining the relationship between immunisation and SIDS.
METHODS
Nine case-controls studies were identified examining this association, of which four adjusted for potential confounders.
RESULTS
The summary odds ratio (OR) in the univariate analysis suggested that immunisations were protective, but the presence of heterogeneity makes it difficult to combine these studies. The summary OR for the studies reporting multivariate ORs was 0.54 (95% CI=0.39-0.76) with no evidence of heterogeneity.
CONCLUSIONS
Immunisations are associated with a halving of the risk of SIDS. There are biological reasons why this association may be causal, but other factors, such as the healthy vaccinee effect, may be important. Immunisations should be part of the SIDS prevention campaigns.
背景
有人声称免疫接种会导致婴儿猝死综合征（SIDS），但一些研究要么未发现关联，要么发现免疫接种与SIDS风险降低有关。
目的
进行一项荟萃分析，研究免疫接种与SIDS之间的关系。
方法
确定了9项研究免疫接种与SIDS关联的病例对照研究，其中4项对潜在混杂因素进行了校正。
结果
单变量分析中的汇总比值比（OR）表明免疫接种具有保护作用，但存在异质性使得难以合并这些研究。报告多变量OR的研究的汇总OR为0.54（95%CI=0.39-0.76），无证据表明存在异质性。
结论
免疫接种与SIDS风险减半有关。这种关联可能存在因果关系的生物学原因，但其他因素，如健康接种者效应，可能也很重要。免疫接种应成为SIDS预防活动的一部分。
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