Lehmann M V, Mardin C Y, Martus P, Bergua A
Department of Ophthalmology, University Erlangen-Nürnberg, Erlangen, Bavaria, Germany.
Eye (Lond). 2008 May;22(5):628-35. doi: 10.1038/sj.eye.6702690. Epub 2007 Mar 30.
Real colour documentation of the optic nerve head (ONH) is one of the most important methods to identify the early progression of glaucomatous optic nerve damage. This study compares the qualitative and semiquantitative evaluation of ONH photographs, using a 3D time-multiplexing system and conventional 2D photography, visualised on a computer monitor.
Stereophotographs of the ONH were converted by special software in a 3D file. The same images were shown in 2D and 3D to 22 subjects with different training grades (residents and ophthalmologists). The evaluation based on a standardised questionnaire, containing semiquantitative parameters of the ONH. A weighted score for quality of ONH assessment counted the correct answers of the observers to compare their evaluation in 2D to the one made in 3D.
All of the observers achieved a significant better evaluation of the ONH with 3D than with 2D images. No significant differences were observed between both groups. Classification errors with respect to the 'gold standard' were lower for 3D measurements as compared with 2D measurements (P=0.007). No significant differences were observed between the gold standard and residents or ophthalmologists for the ONH size, but for the c/dratio the stereoscopic images lead to better results.
This study showed a better evaluation of parameters associated with the glaucomatous ONH atrophy with 3D images compared with 2D, independent of the clinical training grade. The computer-based evaluation of the ONH atrophy by using a time-multiplexing system (shutter-glasses) may improve the diagnosis of glaucoma patients.
对视神经乳头(ONH)进行真实色彩记录是识别青光眼性视神经损害早期进展的最重要方法之一。本研究比较了使用三维时间复用系统和传统二维摄影对视神经乳头照片进行定性和半定量评估的效果,这些照片在计算机显示器上显示。
视神经乳头的立体照片通过特殊软件转换为三维文件。将相同的图像以二维和三维形式展示给22名具有不同培训等级的受试者(住院医师和眼科医生)。基于一份标准化问卷进行评估,问卷包含视神经乳头的半定量参数。对视神经乳头评估质量的加权分数统计观察者的正确答案,以比较他们在二维和三维下的评估结果。
所有观察者对三维图像中视神经乳头的评估均显著优于二维图像。两组之间未观察到显著差异。与二维测量相比,三维测量相对于“金标准”的分类错误更低(P = 0.007)。在视神经乳头大小方面,金标准与住院医师或眼科医生之间未观察到显著差异,但对于杯盘比,立体图像的结果更好。
本研究表明,与二维图像相比,三维图像对视神经乳头萎缩相关参数的评估效果更好,且与临床培训等级无关。使用时间复用系统(快门眼镜)对视神经乳头萎缩进行基于计算机的评估可能会改善青光眼患者的诊断。