Karp H J, Vaihia K P, Kärkkäinen M U M, Niemistö M J, Lamberg-Allardt C J E
Calcium Research Unit, Department of Applied Chemistry and Microbiology, University of Helsinki, Finland.
Calcif Tissue Int. 2007 Apr;80(4):251-8. doi: 10.1007/s00223-007-9011-7. Epub 2007 Apr 1.
The recommended dietary phosphorus intake is exceeded in the typical Western diet. However, few studies have been conducted on the bioavailability and metabolic consequences of dietary phosphorus from different food sources. In this study, acute effects of dietary phosphorus from three different food sources and a phosphate supplement on calcium and bone metabolism were investigated. Sixteen healthy women aged 20-30 years were randomized to five controlled 24-hour study sessions, each subject serving as her own control. At the control session, calcium intake was ca. 250 mg and phosphorus intake ca. 500 mg. During the other four sessions, phosphorus intake was about 1,500 mg, 1,000 mg of which was obtained from meat, cheese, whole grains, or a phosphate supplement, respectively. The foods served were exactly the same during the phosphorus sessions and the control session; only phosphorus sources varied. Markers of calcium and bone metabolism were followed. Analysis of variance with repeated measures was used to compare the study sessions. Only the phosphate supplement increased serum parathyroid hormone (S-PTH) concentration compared with the control session (P = 0.031). Relative to the control session, meat increased markers of both bone formation (P = 0.045) and bone resorption (P = 0.049). Cheese decreased S-PTH (P = 0.0001) and bone resorption (P = 0.008). These data suggest that the metabolic response was different for different foods.
典型的西方饮食中磷的膳食摄入量超过了推荐量。然而，关于不同食物来源的膳食磷的生物利用度和代谢后果的研究却很少。在本研究中，我们调查了三种不同食物来源的膳食磷以及一种磷酸盐补充剂对钙和骨代谢的急性影响。16名年龄在20至30岁之间的健康女性被随机分配到五个24小时的对照研究时段，每个受试者都作为自己的对照。在对照时段，钙摄入量约为250毫克，磷摄入量约为500毫克。在其他四个时段，磷摄入量约为1500毫克，其中1000毫克分别从肉类、奶酪、全谷物或磷酸盐补充剂中获取。在磷摄入时段和对照时段提供的食物完全相同；只是磷的来源不同。我们跟踪了钙和骨代谢的指标。采用重复测量方差分析来比较各研究时段。与对照时段相比，只有磷酸盐补充剂增加了血清甲状旁腺激素（S-PTH）浓度（P = 0.031）。相对于对照时段，肉类增加了骨形成（P = 0.045）和骨吸收（P = 0.049）的指标。奶酪降低了S-PTH（P = 0.0001）和骨吸收（P = 0.008）。这些数据表明，不同食物的代谢反应是不同的。
