Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran 1461884513, Iran.
Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Nutrients. 2024 Jan 24;16(3):344. doi: 10.3390/nu16030344.
Associations between mineral intake and mortality in non-Western countries have not been studied adequately. This study evaluated these associations in the Golestan Cohort Study, featuring a Middle Eastern population. The mineral intake was estimated from the baseline food frequency questionnaire, adjusted by using the nutrient density method, and divided into quintiles. We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the mortality. We analyzed 41,863 subjects with a mean age of 51.46 ± 8.73 years at the baseline. During 578,694 person-years of follow-up (median: 14.1 Years), 7217 deaths were recorded. Dietary calcium intake was inversely associated with the all-cause mortality (HR = 0.91, 95%CI = 0.85-0.99). We observed significant associations between calcium (HR = 0.82, 95% CI = 0.73-0.93), copper (HR = 1.11, 95% CI = 0.99-1.26), and selenium intake (HR = 1.14, 95% CI = 1.01-1.29) and CVD mortality. Dietary phosphorus (HR = 0.81, 95%CI = 0.69-0.96) and copper intake (HR = 0.84, 95%CI = 0.71-0.99) were inversely associated with cancer mortality. In this study within a Middle Eastern population, a higher dietary intake of calcium exhibited an inverse association with all-cause mortality. Furthermore, nuanced associations were observed in the cause-specific mortality, suggesting potential avenues for dietary interventions and emphasizing the importance of considering dietary factors in public health strategies.
在非西方国家，矿物质摄入与死亡率之间的关联尚未得到充分研究。本研究评估了中东人群的戈勒斯坦队列研究中的这些关联。矿物质摄入量是根据基线食物频率问卷估算的，通过营养密度法进行调整，并分为五分位数。我们使用 Cox 比例风险模型来估计死亡率的风险比（HR）和 95％置信区间（CI）。我们分析了 41863 名参与者，基线时的平均年龄为 51.46 ± 8.73 岁。在 578694 人年的随访期间（中位数：14.1 年），记录了 7217 例死亡。膳食钙摄入量与全因死亡率呈负相关（HR = 0.91，95％CI = 0.85-0.99）。我们观察到钙（HR = 0.82，95％CI = 0.73-0.93）、铜（HR = 1.11，95％CI = 0.99-1.26）和硒摄入量（HR = 1.14，95％CI = 1.01-1.29）与心血管疾病死亡率之间存在显著关联。膳食磷（HR = 0.81，95％CI = 0.69-0.96）和铜摄入量（HR = 0.84，95％CI = 0.71-0.99）与癌症死亡率呈负相关。在这项中东人群的研究中，较高的膳食钙摄入量与全因死亡率呈负相关。此外，在特定原因的死亡率中观察到细微的关联，这表明饮食干预的潜在途径，并强调了在公共卫生策略中考虑饮食因素的重要性。
