Abaé M, Gibson M, Chapitis J, Riddick D H, Brumsted J R
Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington.
Fertil Steril. 1992 Mar;57(3):531-4.
To measure uterine fluid CA-125 concentration and to determine if any menstrual cycle phase dependent changes exist in its level. Serum levels are measured for comparison.
CA-125 levels in uterine fluid were measured during the follicular and luteal phases of the menstrual cycle. In a sequential study, paired uterine fluid and serum samples were obtained once in both midfollicular and midluteal phases of the same menstrual cycle.
CA-125 in uterine fluid during the follicular phase (n = 14) ranged from 16.4 x 10(3) to 616.5 x 10(3) U/mL, and from 6.2 x 10(3) to 567.3 x 10(3) U/mL in the luteal phase (n = 11). In the paired sequential uterine fluid and serum samples, (1) the means (+/- SEM) CA-125 in uterine fluid were 81.5 x 10(3) +/- 37.9 x 10(3) U/mL and 91.4 x 10(3) +/- 56.8 x 10(3) U/mL in the midfollicular and midluteal phases, respectively (P = 0.75); (2) the CA-125 levels in serum increased in the midluteal phase (P less than 0.05); and (3) compared with serum, uterine fluid levels were greater with a wider range.
When compared with serum CA-125, uterine fluid contains high concentrations varying over a wide range without fluctuation between the follicular and luteal phases of the menstrual cycle.
测量子宫液中CA - 125浓度，并确定其水平是否存在任何依赖月经周期阶段的变化。测量血清水平以作比较。
在月经周期的卵泡期和黄体期测量子宫液中的CA - 125水平。在一项序贯研究中，在同一个月经周期的卵泡中期和黄体中期各获取一次配对的子宫液和血清样本。
卵泡期（n = 14）子宫液中的CA - 125范围为16.4×10³至616.5×10³U/mL，黄体期（n = 11）为6.2×10³至567.3×10³U/mL。在配对的序贯子宫液和血清样本中，（1）卵泡中期和黄体中期子宫液中CA - 125的均值（±SEM）分别为81.5×10³±37.9×10³U/mL和91.4×10³±56.8×10³U/mL（P = 0.75）；（2）血清中的CA - 125水平在黄体中期升高（P＜0.05）；（3）与血清相比，子宫液水平更高且范围更广。
与血清CA - 125相比，子宫液含有高浓度且范围广泛变化的CA - 125，在月经周期的卵泡期和黄体期之间无波动。
