Venkatesan A, Hemalatha A, Bobby Zachariah, Selvaraj N, Sathiyapriya V
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry.
Indian J Physiol Pharmacol. 2006 Oct-Dec;50(4):403-8.
Glycation is known to play a key role in complications of many pathophysiological processes. The present study was carried out to assess whether there are abnormalities of nonenzymatic glycation of proteins in smokers. Fourteen current smokers and 10 healthy nonsmokers were enrolled for the present study. Fasting plasma glucose, insulin, fructosamine and total plasma glycated proteins were evaluated. A significant rise in the mean levels of fructosamine and total plasma glycated proteins were found in smokers when compared with controls. Significant difference in insulin values was observed between these two groups. When Pearson's correlation analysis was performed, no significant correlation was found between fasting plasma glucose with either fructosamine or total plasma glycated protein levels. These data suggest an increased glycation of proteins in smokers independent of glucose concentration.
已知糖基化在许多病理生理过程的并发症中起关键作用。本研究旨在评估吸烟者蛋白质非酶糖基化是否存在异常。本研究纳入了14名当前吸烟者和10名健康非吸烟者。评估了空腹血糖、胰岛素、果糖胺和总血浆糖化蛋白。与对照组相比，吸烟者的果糖胺和总血浆糖化蛋白平均水平显著升高。两组间胰岛素值存在显著差异。进行Pearson相关性分析时，空腹血糖与果糖胺或总血浆糖化蛋白水平之间未发现显著相关性。这些数据表明吸烟者蛋白质糖基化增加，且与葡萄糖浓度无关。
