两亲性聚合物微粒的合成与自组装

Synthesis and self-assembly of amphiphilic polymeric microparticles.

作者信息

Dendukuri Dhananjay, Hatton T Alan, Doyle Patrick S

机构信息

Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

出版信息

Langmuir. 2007 Apr 10;23(8):4669-74. doi: 10.1021/la062512i.

DOI:10.1021/la062512i

PMID:17402702

Abstract

We report the synthesis and self-assembly of amphiphilic, nonspherical, polymeric microparticles. Wedge-shaped particles bearing segregated hydrophilic and hydrophobic sections were synthesized in a microfludic channel by polymerizing across laminar coflowing streams of hydrophilic and hydrophobic polymers using continuous flow lithography (CFL). Particle monodispersity was characterized by measuring both the size of the particles formed and the extent of amphiphilicity. The coefficient of variation (COV) was found to be less than 2.5% in all measured dimensions. Particle structure was further characterized by measuring the curvature of the interface between the sections and the extent of cross-linking using FTIR spectroscopy. The amphiphilic particles were allowed to self-assemble in water or at water-oil interfaces. In water, the geometry of the particles enabled the formation of micelle-like structures, while in emulsions, the particles migrated to the oil-water interface and oriented themselves to minimize their surface energy.

摘要

我们报道了两亲性、非球形聚合物微粒的合成与自组装。通过使用连续流光刻技术（CFL），使亲水性和疏水性聚合物在层流共流的微流体通道中聚合，合成了带有分离的亲水性和疏水性部分的楔形颗粒。通过测量所形成颗粒的大小和两亲性程度来表征颗粒的单分散性。在所有测量尺寸中，变异系数（COV）均小于2.5%。通过使用傅里叶变换红外光谱（FTIR）测量各部分之间界面的曲率和交联程度，进一步表征了颗粒结构。使两亲性颗粒在水中或水-油界面处自组装。在水中，颗粒的几何形状能够形成类似胶束的结构，而在乳液中，颗粒迁移至油水界面并自行排列以使其表面能最小化。