Swartz Karin R, Fee Dominic B, Joy Kelly M, Roberts Kelly N, Sun Sophie, Scheff Nicole N, Wilson Melinda E, Scheff Stephen W
Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA.
J Neurotrauma. 2007 Mar;24(3):473-80. doi: 10.1089/neu.2006.0167.
Recent attention has been given to gender differences in neurotrauma, and the anecdotal suggestion is that females have better outcomes than males, suggesting that circulating levels of estrogen (E(2)) may be neuroprotective. In order to address this issue, both young adult male and ovariectomized female rats were subjected to a T10 spinal cord injury (SCI), and E2 levels were maintained at chronic, constant circulating levels. Animals were clinically evaluated for locomotor changes using the Basso-Beattie-Bresnahan (BBB) scoring system. Morphologic differences were evaluated with unbiased stereology. Data analysis failed to reveal any significant benefit for the E2 therapy in either males or females. We did find a non-estrogen-dependent difference between male and female rats in length of injury, and percent of spared tissue, with female outcomes more favorable. These results suggest that E(2) does not provide a viable therapy following SCI.
近期，神经创伤方面的性别差异受到了关注，有传闻称女性的预后比男性更好，这表明循环中的雌激素（E2）水平可能具有神经保护作用。为了解决这个问题，对年轻成年雄性大鼠和去卵巢雌性大鼠均造成T10脊髓损伤（SCI），并将E2水平维持在慢性、恒定的循环水平。使用Basso-Beattie-Bresnahan（BBB）评分系统对动物的运动变化进行临床评估。用无偏体视学评估形态学差异。数据分析未能揭示E2治疗对雄性或雌性大鼠有任何显著益处。我们确实发现雄性和雌性大鼠在损伤长度和 spared组织百分比方面存在非雌激素依赖性差异，雌性的预后更有利。这些结果表明，SCI后E2不能提供可行的治疗方法。
