Lu Xue-yi, Xu Jian-min, Zhong Yun-shi, Ren Li, Lai Yan-han, Qin Xin-yu
Department of General Practice, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhonghua Wai Ke Za Zhi. 2007 Jan 1;45(1):54-7.
To investigate the expression of cyclooxygenase-2 (COX-2) in colorectal carcinoma and its correlation with liver metastasis of colorectal carcinoma.
The expression of COX-2 was detected using immunohistochemical methods in 30 colorectal carcinoma tissues without liver metastasis, 30 with preoperative liver metastasis, 30 with postoperative liver metastasis and 30 surrounding normal colorectal tissues. And its correlation with gender, age, Dukes stages was analyzed too.
The expression of COX-2 in colorectal carcinoma was significantly higher than that in surrounding normal colorectal tissue (P < 0.05), and meanwhile, its level in colorectal carcinoma without liver metastasis was significantly lower than those in tissues with preoperative or postoperative liver metastasis (P < 0.05). The COX-2 level had no correlation with gender, age, histological type, histological grade or the preoperative serum CEA and CA 19-9 levels in colorectal carcinoma (P > 0.05), but it was related to Dukes stages and lymph node metastasis.
COX-2 plays a role in the course of generation, development and metastasis of colorectal carcinoma. The high expression of COX-2 in colorectal carcinoma tissues may be considered as an indicator for liver metastasis.
探讨环氧化酶-2（COX-2）在结直肠癌中的表达及其与结直肠癌肝转移的相关性。
采用免疫组化方法检测30例无肝转移的结直肠癌组织、30例术前有肝转移的结直肠癌组织、30例术后有肝转移的结直肠癌组织及30例结直肠周围正常组织中COX-2的表达，并分析其与性别、年龄、Dukes分期的相关性。
结直肠癌中COX-2的表达明显高于结直肠周围正常组织（P<0.05），同时，无肝转移的结直肠癌组织中COX-2水平明显低于术前或术后有肝转移的组织（P<0.05）。COX-2水平与结直肠癌患者的性别、年龄、组织学类型、组织学分级或术前血清CEA和CA 19-9水平无关（P>0.05），但与Dukes分期及淋巴结转移有关。
COX-2在结直肠癌的发生、发展及转移过程中起作用。结直肠癌组织中COX-2的高表达可作为肝转移的一个指标。
