Luini Alberto, Gatti Giovanna, Zurrida Stefano, Talakhadze Nina, Brenelli Fabricio, Gilardi Daniela, Paganelli Giovanni, Orecchia Roberto, Cassano Enrico, Viale Giuseppe, Sangalli Claudia, Ballardini Bettina, dos Santos Gabriela Rosali, Veronesi Umberto
Division of Breast Surgery, European Institute of Oncology, via Ripamonti 435, Milan, Italy.
Breast. 2007 Apr;16(2):120-9. doi: 10.1016/j.breast.2006.11.001.
The profound revolution that surgical treatment of breast cancer has undergone during the past 30 years has led to the progressive reduction of the extent of surgery, with less mutilation. As a consequence, quality of life has improved and women are now more motivated to follow screening programs for early diagnosis of the disease. Since conservative surgery is as effective as radical surgery, research is now focused on reducing radiotherapy. Overall, survival after breast cancer is not affected by reducing the extent of surgery, which, together with less invasive diagnostic procedures, has a good effect on patients' quality of life. For this reason in our Institute we are now evaluating the feasibility of a reduction of the radiation field and the sensibility and sensitivity of new diagnostic approaches for axillary staging.
在过去30年里，乳腺癌外科治疗经历了深刻变革，手术范围逐渐缩小，致残性降低。因此，生活质量得到改善，女性现在更有动力参与筛查项目以实现疾病的早期诊断。由于保乳手术与根治性手术效果相同，目前研究重点在于减少放疗。总体而言，乳腺癌术后生存率不受手术范围缩小的影响，这与侵入性较小的诊断程序一起，对患者生活质量有良好影响。出于这个原因，我们研究所目前正在评估缩小放疗范围的可行性以及腋窝分期新诊断方法的敏感性和特异性。
