Luini Alberto, Gatti Giovanna, Galimberti Viviana, Zurrida Stefano, Intra Mattia, Gentilini Oreste, Paganelli Giovanni, Viale Giuseppe, Orecchia Roberto, Veronesi Paolo, Veronesi Umberto
Division of Breast Surgery, European Institute of Oncology, Milan, Italy.
Breast Cancer Res Treat. 2005 Dec;94(3):195-8. doi: 10.1007/s10549-004-7376-0.
Over recent decades, breast carcinoma surgery has witnessed a considerable evolution. The extent of surgery undertaken has progressively reduced, leading to less disfigurement and a significant improvement in quality of life, thereby offering women considerable motivation to seek early diagnosis. From an oncological perspective, outcome was found to be equally effective, and this key observation provided us with significant impetus to investigate the effects of reducing the radiotherapy field.
We present the achievements made so far in the conservative treatment of breast carcinoma, based on experiences at the European Institute of Oncology in Milan and, prior to 1994, at the Milan Cancer Institute.
Conservative surgery of breast carcinoma, both in the breast and in the axillary nodes, has yielded very good results in terms of overall survival and impact on quality of life. The reduction of the radiation field, conducted in our Institute by means of electron intraoperative radiotherapy (ELIOT), is currently the subject of evaluation via a randomised trial.
近几十年来，乳腺癌手术经历了相当大的演变。所进行手术的范围逐渐缩小，导致毁容程度降低，生活质量显著提高，从而为女性提供了寻求早期诊断的强大动力。从肿瘤学角度来看，结果显示同样有效，这一关键观察结果为我们研究缩小放疗范围的效果提供了重要动力。
我们基于米兰欧洲肿瘤研究所的经验以及1994年之前在米兰癌症研究所的经验，介绍目前在乳腺癌保守治疗方面所取得的成果。
乳腺癌的保守手术，包括乳房和腋窝淋巴结的手术，在总体生存率和对生活质量的影响方面都取得了非常好的结果。我们研究所通过术中电子放疗（ELIOT）进行的放疗范围缩小，目前正通过一项随机试验进行评估。
