Weiler H A, Kovacs H, Nitschmann E, Bankovic-Calic N, Aukema H, Ogborn M
School of Dietetics and Human Nutrition, McGill University, Ste. Anne de Bellevue, Que., Canada H9X 3V9.
Prostaglandins Leukot Essent Fatty Acids. 2007 May;76(5):269-75. doi: 10.1016/j.plefa.2007.02.001. Epub 2007 Apr 2.
Flaxseed's oil and lignan, secoisolariciresinol diglucoside (SDG), are implicated in attainment of health and treatment of renal injury and osteoporosis. To test for these benefits, weanling Han:SPRD-cy rats (n=171) with or without kidney disease were randomized to diets made with either corn oil or flaxseed oil and with or without SDG for 12 weeks. In females, weight was lower with the SDG diet. In males fed flaxseed oil, lean mass was higher and fat % was lower. In both sexes, fat % was lower in diseased rats. Bone mineral content (BMC) and density were higher in rats fed flaxseed oil and lower in diseased rats, additionally; BMC was lower in SDG-supplemented females. The benefit of flaxseed oil on body composition is sex specific but the effect on bone mass is not. Lastly, reduced weight due to early rat kidney disease is not due to loss of lean body mass.
亚麻籽的油和木脂素，即开环异落叶松脂素二葡萄糖苷（SDG），与健康的维持以及肾损伤和骨质疏松症的治疗有关。为了测试这些益处，将患有或未患有肾脏疾病的断乳期Han:SPRD-cy大鼠（n = 171）随机分为以玉米油或亚麻籽油制成的饮食组，并分别添加或不添加SDG，持续12周。在雌性大鼠中，食用含SDG饮食的体重较低。在喂食亚麻籽油的雄性大鼠中，瘦体重较高而脂肪百分比较低。在两性中，患病大鼠的脂肪百分比均较低。此外，喂食亚麻籽油的大鼠骨矿物质含量（BMC）和骨密度较高，而患病大鼠则较低；补充SDG的雌性大鼠的BMC较低。亚麻籽油对身体成分的益处具有性别特异性，但对骨量的影响并非如此。最后，早期大鼠肾脏疾病导致的体重减轻并非由于瘦体重的减少。
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