Yoshimura N, Kuriyama S, Ohuchi T, Takemura M, Honda Y, Hiraoka M
Department of Ophthalmology, Kyoto University Faculty of Medicine, Japan.
Invest Ophthalmol Vis Sci. 1992 Feb;33(2):404-9.
The effects of hyperthermia on experimental proliferative vitreoretinopathy (PVR) in rabbits were studied. Heat treatment (42.4 degrees C for 30 min) of the retinal surface (as estimated from temperature measurement of the retrobulbar space) 2 to 3 hr after fibroblast injection reduced the occurrence of traction retinal detachment compared with control rabbits (P less than 0.02), but the incidence of pucker formation plus traction detachment was not significantly different between the two groups. In a separate experiment, heat treatment applied to normal rabbit eyes showed only reversible elongation in the latency of the electroretinographic b-wave without affecting the amplitude. Histologic examination revealed no significant changes in the heat-treated normal rabbit retina. Hyperthermia may be used as a new therapeutic tool for PVR.
研究了热疗对兔实验性增殖性玻璃体视网膜病变（PVR）的影响。在成纤维细胞注射后2至3小时对视网膜表面进行热处理（42.4℃，30分钟）（根据球后间隙温度测量估算），与对照兔相比，牵引性视网膜脱离的发生率降低（P<0.02），但两组之间皱襞形成加牵引性脱离的发生率无显著差异。在另一项实验中，对正常兔眼进行热疗仅显示视网膜电图b波潜伏期出现可逆性延长，而不影响振幅。组织学检查显示，热疗后的正常兔视网膜无明显变化。热疗可能成为治疗PVR的一种新的治疗手段。
