松果体切除以及松果体切除联合胸腺切除对大鼠多瘤病毒致癌作用的影响。
The influence of pinealectomy and of pinealectomy combined with thymectomy oncogenesis caused by polyoma virus in rats.
作者信息
Wrba H, Lapin V, Dostal V
出版信息
Osterr Z Onkol. 1975;2(2-3):37-9.
The inoculation of Polyoma virus suspension to neonatal pinealectomized rats did not provoke a growth of neoplasia. However, if the pinealectomy was combined with neonatal thymectomy, renal tumors occured in a rate of 50 of animals. An incidence of renal tumors was observed also in 57.6% of thymectomized rats, but not in non operated control group. The stimulating effect of pinealectomy on the growth of transplantable tumors has already been described several times (2, 3, 6, 8). The question of a possible change in the viral oncogenesis after pinealectomy was raised. For this reason Polyoma virus was used and its oncogenic effect was studied on the neonatally pinealectomized rats, on rats neonatally thymectomized and on neonatally pinealectomized rats which were simultaneously thymectomized.
将多瘤病毒悬液接种到新生期松果体切除的大鼠中，并未引发肿瘤生长。然而，如果松果体切除与新生期胸腺切除相结合，50%的动物会发生肾肿瘤。在胸腺切除的大鼠中也观察到肾肿瘤发生率为57.6%，但在未手术的对照组中未观察到。松果体切除对可移植肿瘤生长的刺激作用已被多次描述（2、3、6、8）。有人提出了松果体切除后病毒致癌作用可能发生变化的问题。因此，使用了多瘤病毒，并研究了其对新生期松果体切除的大鼠、新生期胸腺切除的大鼠以及同时进行松果体切除和胸腺切除的新生期大鼠的致癌作用。
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