Kawasaki Naruo, Nakada Koji, Nakayoshi Tomoko, Furukawa Yoshiyuki, Suzuki Yutaka, Hanyu Nobuyoshi, Yanaga Katsuhiko
Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Dig Dis Sci. 2007 Oct;52(10):2684-94. doi: 10.1007/s10620-006-9391-y. Epub 2007 Apr 3.
The purpose of this study was to investigate the effects of the herbal medicine dai-kenchu-to on gastrointestinal motility based on differences in the administration site and timing. We sutured strain-gauge transducers to the stomach (three), duodenum (one), jejunum (one), ileum (one), and colon (two) and inserted indwelling tubes into the stomach, jejunum, and proximal colon of beagles. Dai-kenchu-to was administered to each site during the fasting or fed state. During the fasting state, the prokinetic effects of dai-kenchu-to were evident at all administration sites. The effects were attenuated during the fed state. With intracolonic administration, a contraction similar to the giant migrating contraction-like contraction was induced during the fasting and the fed state, and defecation occurred. Despite the differences in administration site and timing, no contraction complex appeared orad to the administration sites. These results indicate that the prokinetic effects of dai-kenchu-to differ with the site or timing of administration.
本研究旨在基于给药部位和时间的差异，探讨草药大建中汤对胃肠动力的影响。我们将应变片式传感器缝合到犬的胃（三个）、十二指肠（一个）、空肠（一个）、回肠（一个）和结肠（两个），并将留置管插入到比格犬的胃、空肠和近端结肠。在禁食或进食状态下将大建中汤给予各个部位。在禁食状态下，大建中汤在所有给药部位均表现出促动力作用。在进食状态下，这些作用减弱。结肠内给药时，在禁食和进食状态下均诱导出类似于巨大移行收缩样的收缩，并出现排便。尽管给药部位和时间存在差异，但在给药部位近端未出现收缩复合波。这些结果表明，大建中汤的促动力作用因给药部位或时间的不同而有所差异。
