Shibata C, Sasaki I, Naito H, Ueno T, Matsuno S
First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.
Surgery. 1999 Nov;126(5):918-24.
The herbal medicine Dai-Kenchu-To, composed of zanthoxylum fruit, ginseng root, and dried ginger rhizome, is clinically effective for uncomplicated postoperative adhesive intestinal obstruction. We investigated the effect of Dai-Kenchu-To and each ingredient on upper gastrointestinal motility and its mechanism of action.
Five mongrel dogs were equipped with 4-strain gauge-force transducers on the gastric body, antrum, duodenum, and jejunum to measure contractile activity of the circular muscle. Dai-Kenchu-To (1.5 g) or the separate ingredients zanthoxylum fruit, ginseng root, or dried ginger rhizome (1.0 g each) were administered by bolus into the gastric lumen. The effect of atropine, hexamethonium, phentolamine, propranolol, and ondansetron on intragastric Dai-Kenchu-To-induced contractions was studied.
Intragastric Dai-Kenchu-To induced phasic contractions in the antrum, duodenum, and jejunum. Zanthoxylum fruit elicited phasic contractions mainly in the duodenum and jejunum, whereas dried ginger rhizome induced phasic contractions in the antrum. Ginseng root had no effect. Phasic contractions induced by intragastric Dai-Kenchu-To were inhibited by atropine and hexamethonium at all sites, although ondansetron inhibited these contractions in the antrum and duodenum.
Intragastric Dai-Kenchu-To stimulates upper gastrointestinal motility through cholinergic and 5-hydroxytryptamine 3 receptors.
草药大建中汤由花椒、人参根和干姜根茎组成，对单纯性术后粘连性肠梗阻具有临床疗效。我们研究了大建中汤及其各成分对上消化道运动的影响及其作用机制。
对5只杂种犬的胃体、胃窦、十二指肠和空肠安装4应变片式力传感器，以测量环行肌的收缩活动。将大建中汤（1.5 g）或单独成分花椒、人参根或干姜根茎（各1.0 g）经胃腔推注给药。研究了阿托品、六甲铵、酚妥拉明、普萘洛尔和昂丹司琼对胃内大建中汤诱导收缩的影响。
胃内大建中汤可引起胃窦、十二指肠和空肠的相性收缩。花椒主要引起十二指肠和空肠的相性收缩，而干姜根茎则引起胃窦的相性收缩。人参根无作用。胃内大建中汤诱导的相性收缩在所有部位均被阿托品和六甲铵抑制，尽管昂丹司琼抑制胃窦和十二指肠的这些收缩。
胃内大建中汤通过胆碱能和5-羟色胺3受体刺激上消化道运动。
