Hardcastle J D, Mann C V
Gut. 1970 Jan;11(1):41-6. doi: 10.1136/gut.11.1.41.
The effect of colonic distension and changes in intraluminal pH and osmolality have been investigated in patients with well established colostomies. Small volumes of acidic buffer (pH4) and hypertonic saline (4%) were found to be only a very weak peristaltic stimulus. Strong hypertonic solutions (glycerine BP) induced a poorly sustained peristaltic response in the majority of cases. Distension of the inactive colon did not stimulate peristalsis. Distension of a colon previously stimulated to peristaltic activity caused fresh waves of contraction. This study appears to show that by themselves physical factors play an unimportant role in initiating peristaltic activity in the colon.
已对患有成熟结肠造口术的患者进行了结肠扩张以及管腔内pH值和渗透压变化影响的研究。发现小剂量的酸性缓冲液(pH4)和高渗盐水(4%)只是非常微弱的蠕动刺激。在大多数情况下,强高渗溶液(英国药典甘油)引起的蠕动反应持续时间较短。无活性结肠的扩张不会刺激蠕动。先前已被刺激产生蠕动活动的结肠扩张会引发新的收缩波。这项研究似乎表明,物理因素本身在引发结肠蠕动活动中起的作用并不重要。