Drabik Anna, Bierczynska-Krzysik Anna, Bodzon-Kulakowska Anna, Suder Piotr, Kotlinska Jolanta, Silberring Jerzy
Faculty of Chemistry and Regional Laboratory, Jagiellonian University, Krakow, Poland.
Mass Spectrom Rev. 2007 May-Jun;26(3):432-50. doi: 10.1002/mas.20131.
This review provides an outline of the most important proteomic applications in the study of neurodegenerative disorders including Alzheimer's (AD), Parkinson's (PD), Huntington's (HD), and prion diseases, and also discusses advances in cancer and addiction. One of the scopes is to illustrate the potential of proteomics in the biomarkers discovery of these diseases. Finally, this article comments the advantages and drawbacks of the most commonly used techniques and methods for samples preparation.
本综述概述了蛋白质组学在神经退行性疾病研究中的最重要应用，包括阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）和朊病毒病，同时也讨论了癌症和成瘾方面的进展。其中一个目的是说明蛋白质组学在这些疾病生物标志物发现中的潜力。最后，本文对最常用的样本制备技术和方法的优缺点进行了评论。
