Elisevich Kost, Jenrow Ken, Schuh Lori, Smith Brien
Departments of Neurosurgery and Neurology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
J Neurosurg. 2006 Dec;105(6):894-7. doi: 10.3171/jns.2006.105.6.894.
The aim of this study was to determine the effects of long-term continuous cerebrocortical electrical stimulation in the treatment of partial epilepsy. The authors review the case of a 44-year-old man with medically intractable postencephalitic localization-related epilepsy with ictal onset in the primary motor cortex. For 5 years he was treated using patterned subthreshold electrical stimulation of the ictal site. This therapy has successfully eliminated the jacksonian march of cortical excitability and secondary generalization and reduced seizure frequency and intensity with an immediate postictal return of motor function. Over time, the seizure frequency subsided by more than 90%, with the patient showing no adverse features resulting from focal stimulation. The results in this case support the hypothesis that effective and safe long-term modulation of focal epilepsy is possible with focal cerebrocortical electrical stimulation.
本研究的目的是确定长期持续脑皮质电刺激治疗部分性癫痫的效果。作者回顾了一例44岁男性患者的病例，该患者患有药物难治性脑炎后定位相关癫痫，发作起始于初级运动皮层。5年来，他接受了发作部位的模式化阈下电刺激治疗。该疗法成功消除了皮质兴奋性的杰克逊癫痫发作进展和继发性泛化，降低了癫痫发作频率和强度，发作后运动功能立即恢复。随着时间的推移，癫痫发作频率下降了90%以上，患者未出现局灶性刺激导致的不良特征。该病例的结果支持了这样一种假设，即通过局灶性脑皮质电刺激对局灶性癫痫进行有效且安全的长期调节是可行的。
