贯叶连翘提取物对MPTP诱导的小鼠帕金森病中星形胶质细胞的调节作用。
Modulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson's disease in mice.
作者信息
Mohanasundari M, Sabesan M
机构信息
Department of Zoology, Annamalai University, Annamalainagar 608 002, Tamilnadu, India.
出版信息
Eur Rev Med Pharmacol Sci. 2007 Jan-Feb;11(1):17-20.
The present study has been evaluated the neuroprotective effect of Hypericum perforatum extract on the reaction of astrocytes in mice brain treated with an intraperitoneal injection of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (20 mg/kg with 2 hr intervals). Treatment with Hypericum perforatum extract (HPE) resulted in an inhibition of monoamine oxidase-B (MAO-B) activity and reduced astrocyte activation in striatal area induced by MPTP. The results show that HPE has neuromodulating effect against MPTP induced Parkinson's disease in mice.
本研究评估了贯叶连翘提取物对腹腔注射1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）（20mg/kg，间隔2小时）处理的小鼠脑内星形胶质细胞反应的神经保护作用。贯叶连翘提取物（HPE）处理可抑制单胺氧化酶-B（MAO-B）活性，并减少MPTP诱导的纹状体区域星形胶质细胞活化。结果表明，HPE对MPTP诱导的小鼠帕金森病具有神经调节作用。
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