Department of Pharmacology, I. S. F. College of Pharmacy, Moga, 142001, Punjab, India.
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Naunyn Schmiedebergs Arch Pharmacol. 2022 May;395(5):495-513. doi: 10.1007/s00210-022-02223-5. Epub 2022 Mar 8.
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons, leading to misbalance and loss of coordination. Current therapies are claimed only for symptomatic relief, on long-term use, which causes alteration in basal ganglia, and give rise to various adverse effects like dyskinesia and extra pyramidal side effects, which is reversed and proved to be attenuated with the help of various herbal approaches. Therefore, in order to attenuate the dopaminergic complications, focus of current research has been shifted from dopaminergic to non-dopaminergic strategies. Herbs and herbal remedies seems to be a better option to overcome the complications associated with current dopaminergic therapies. In recent years, various herbs and herbal remedies based on Ayurveda, traditional Chinese and Korean remedies, have become the target of various researches. These herbs and their bioactive compound are being extensively used to treat PD in India, China, Japan, and Korea. The major focus of this current review is to analyze preclinical studies with reference to various herbs, bioactive compounds, and traditional remedies for the management of Parkinson disorder, which will give an insight towards clinical trials.
帕金森病（PD）的特征是多巴胺能神经元进行性退化，导致平衡和协调丧失。目前的治疗方法仅声称可缓解症状，长期使用会导致基底神经节发生变化，并引起各种不良反应，如运动障碍和锥体外系副作用，这些副作用可以通过各种草药方法得到逆转和减轻。因此，为了减轻多巴胺能并发症，目前的研究重点已经从多巴胺能策略转移到非多巴胺能策略。草药和草药疗法似乎是克服与当前多巴胺能疗法相关的并发症的更好选择。近年来，基于阿育吠陀、传统中医和韩国疗法的各种草药和草药疗法已成为各种研究的目标。这些草药及其生物活性化合物在印度、中国、日本和韩国被广泛用于治疗帕金森病。本综述的主要重点是分析与各种草药、生物活性化合物和传统疗法相关的临床前研究，为管理帕金森病提供参考，这将为临床试验提供深入了解。
