Reid M J, Nish W A, Whisman B A, Goetz D W, Hylander R D, Parker W A, Freeman T M
Division of Medicine, Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas.
J Allergy Clin Immunol. 1992 Feb;89(2):593-8. doi: 10.1016/0091-6749(92)90327-x.
We did human lymphocyte antigen (HLA)-DR and DQ typing on 37 subjects with mountain-cedar (MC) pollinosis as defined by history and a positive skin test. Of these 37 subjects, 31 were subdivided into 18 subjects with a single positive skin test (SPST) and 13 subjects with multiple positive skin tests (MPSTs). We also typed 51 subjects without MC sensitivity or atopy as defined by history and negative skin tests to a battery of aeroallergens. We also typed 116 subjects in whom MC sensitivity had not been determined. Total IgE, Mc-specific immunoglobulin E (sIgE), and MC-sIgE binding bands by immunoblot were also determined on the subjects with SPSTs and MPSTs. No significant differences were found between the subjects with SPSTs and MPSTs for HLA type, total IgE, MC sIgE, or bands bound by MC sIgE by immunoblot. There was a strong negative relationship between HLA-DR4 and subjects with MC pollinosis; chi-square, 14.857; p = 0.0096; and odds ratio, 0.139. These findings suggest that there is no difference in genetic immunoregulation between subjects with SPSTs and MPSTs but that the presence of the DR4 gene product is associated with a decreased risk of an IgE response to MC and protection from MC pollenosis.
我们对37名有山雪松（MC）花粉症病史且皮肤试验呈阳性的受试者进行了人类白细胞抗原（HLA）-DR和DQ分型。在这37名受试者中，31名被细分为18名单一阳性皮肤试验（SPST）受试者和13名多重阳性皮肤试验（MPST）受试者。我们还对51名无MC敏感性或特应性病史且对一系列气传变应原皮肤试验呈阴性的受试者进行了分型。我们也对116名尚未确定MC敏感性的受试者进行了分型。还对SPST和MPST受试者测定了总IgE、MC特异性免疫球蛋白E（sIgE）以及免疫印迹法检测的MC-sIgE结合带。在SPST和MPST受试者之间，HLA类型、总IgE、MC sIgE或免疫印迹法检测的MC sIgE结合带均未发现显著差异。HLA-DR4与MC花粉症受试者之间存在很强的负相关关系；卡方值为14.857；p = 0.0096；优势比为0.139。这些发现表明，SPST和MPST受试者之间在基因免疫调节方面没有差异，但DR4基因产物的存在与对MC的IgE反应风险降低以及预防MC花粉症有关。
