Guze B H, Hoffman J M, Mazziotta J C, Baxter L R, Phelps M E
Department of Radiological Sciences, UCLA.
J Am Geriatr Soc. 1992 Feb;40(2):120-3. doi: 10.1111/j.1532-5415.1992.tb01930.x.
Local cerebral metabolic rates for glucose were compared between patients with familial Alzheimer's disease (FAD), sporadic Alzheimer's Disease (SAD), and normal controls (NC) to determine if FAD is associated with a unique pattern of brain metabolism.
Case-control study matched to convenience sample of FAD.
Subjects in the three diagnostic groups were scanned using fluorodeoxyglucose and the Positron Emission Tomographic (PET) technique. The criterion standard of a detailed clinical history and examination were compared to scan results.
Patients in a university hospital.
Ambulatory controls and Alzheimer's patients, both sporadic (n = 8) and familial (n = 7). The two groups were similar in severity of cognitive dysfunction.
FAD and SAD patients did not significantly differ in terms of local cerebral metabolic rates for glucose.
比较家族性阿尔茨海默病（FAD）患者、散发性阿尔茨海默病（SAD）患者和正常对照（NC）之间的局部脑葡萄糖代谢率，以确定FAD是否与独特的脑代谢模式相关。
与FAD便利样本匹配的病例对照研究。
使用氟脱氧葡萄糖和正电子发射断层扫描（PET）技术对三个诊断组的受试者进行扫描。将详细临床病史和检查的标准对照与扫描结果进行比较。
一家大学医院的患者。
门诊对照以及散发性（n = 8）和家族性（n = 7）阿尔茨海默病患者。两组在认知功能障碍严重程度方面相似。
FAD和SAD患者在局部脑葡萄糖代谢率方面无显著差异。
