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常染色体显性遗传性阿尔茨海默病:脑葡萄糖代谢

Dominantly inherited Alzheimer's disease: cerebral glucose metabolism.

作者信息

Polinsky R J, Noble H, Di Chiro G, Nee L E, Feldman R G, Brown R T

出版信息

J Neurol Neurosurg Psychiatry. 1987 Jun;50(6):752-7. doi: 10.1136/jnnp.50.6.752.

DOI:10.1136/jnnp.50.6.752
PMID:3497227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1032083/
Abstract

Cerebral glucose metabolic rate (CMRGlu), measured by positron emission tomography, was bilaterally and symmetrically reduced in two patients with autosomal dominant Alzheimer's disease. Supramarginal gyri and temporal lobes were most severely affected. An isolated reduction of CMRGlu in the left supramarginal gyrus was observed in one asymptomatic at-risk subject.

摘要

通过正电子发射断层扫描测量的脑葡萄糖代谢率(CMRGlu)在两名常染色体显性阿尔茨海默病患者中双侧对称降低。缘上回和颞叶受影响最为严重。在一名无症状高危受试者中观察到左侧缘上回CMRGlu单独降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/1032083/dd62f80e99aa/jnnpsyc00553-0098-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/1032083/834f375f7349/jnnpsyc00553-0097-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/1032083/bf262570ab12/jnnpsyc00553-0098-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/1032083/dd62f80e99aa/jnnpsyc00553-0098-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/1032083/834f375f7349/jnnpsyc00553-0097-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/1032083/bf262570ab12/jnnpsyc00553-0098-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f92/1032083/dd62f80e99aa/jnnpsyc00553-0098-b.jpg

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本文引用的文献

1
ALZHEIMER'S PRESENILE DEMENTIA. A HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDY.早老性阿尔茨海默病痴呆:一项组织化学与电子显微镜研究
Lab Invest. 1965 Apr;14:381-96.
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FAMILIAL ALZHEIMER'S DISEASE.家族性阿尔茨海默病
Neurology. 1963 Oct;13:811-24. doi: 10.1212/wnl.13.10.811.
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Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography.痴呆症患者大脑局部的氧供应与利用:一项使用氧-15和正电子断层扫描技术的临床与生理学研究
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The earliest cognitive change in a person with familial Alzheimer's disease: presymptomatic neuropsychological features in a pedigree with familial Alzheimer's disease confirmed at necropsy.家族性阿尔茨海默病患者最早出现的认知变化:尸检确诊的家族性阿尔茨海默病家系的症状前神经心理学特征。
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Regional cortical dysfunction in Alzheimer's disease as determined by positron emission tomography.通过正电子发射断层扫描确定的阿尔茨海默病中的局部皮质功能障碍。
Ann Neurol. 1984;15 Suppl:S170-4. doi: 10.1002/ana.410150732.
5
The fluorodeoxyglucose 18F scan in Alzheimer's disease and multi-infarct dementia.18F氟代脱氧葡萄糖扫描在阿尔茨海默病和多发梗死性痴呆中的应用
Arch Neurol. 1983 Nov;40(12):711-4. doi: 10.1001/archneur.1983.04050110029003.
6
Alzheimer's disease: focal cortical changes shown by positron emission tomography.阿尔茨海默病:正电子发射断层扫描显示的局灶性皮质改变
Neurology. 1983 Aug;33(8):961-5. doi: 10.1212/wnl.33.8.961.
7
Computed tomography and positron emission transaxial tomography evaluations of normal aging and Alzheimer's disease.计算机断层扫描和正电子发射断层扫描对正常衰老和阿尔茨海默病的评估。
J Cereb Blood Flow Metab. 1983 Sep;3(3):391-4. doi: 10.1038/jcbfm.1983.57.
8
Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose.阿尔茨海默型痴呆的脑区代谢改变:[18F]氟脱氧葡萄糖正电子发射断层扫描
J Comput Assist Tomogr. 1983 Aug;7(4):590-8. doi: 10.1097/00004728-198308000-00003.
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A family with histologically confirmed Alzheimer's disease.一个经组织学确诊为阿尔茨海默病的家族。
Arch Neurol. 1983 Apr;40(4):203-8. doi: 10.1001/archneur.1983.04050040033004.
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Positron emission tomographic studies of aging and Alzheimer disease.衰老与阿尔茨海默病的正电子发射断层扫描研究
AJNR Am J Neuroradiol. 1983 May-Jun;4(3):568-71.