2'-氯-2'-脱氧核苷、核苷酸和多核苷酸水解生成阿拉伯糖衍生物。
Hydrolysis in 2'-chloro-2'-deoxy nucleosides, -nucleotides and -polynucleotides to arabinose-derivatives.
作者信息
Hobbs J, Eckstein F
出版信息
Nucleic Acids Res. 1975 Oct;2(10):1987-94. doi: 10.1093/nar/2.10.1987.
Abstract
The rate of hydrolysis of 2'-chloro-2'-deoxycytidine and -uridine, and their 5'-phosphates, -diphosphates and polymers to the corresponding arabinocytidine and arabinouridine derivatives in the presence of Tris-HCL pH 8.9 is determined. This rate is highest for the nucleosides, less for the 5'-phosphates and 5'-diphosphates and even less for the polynucleotides. In the the 2'-chloro-2'-deoxyuridine series the O2, 2'-cyclonucleoside was formed in addition to the arabinonucleoside.
摘要
测定了2'-氯-2'-脱氧胞苷和-尿苷及其5'-磷酸酯、-二磷酸酯和聚合物在Tris-HCL pH 8.9存在下向相应阿糖胞苷和阿糖尿苷衍生物的水解速率。核苷的水解速率最高，5'-磷酸酯和5'-二磷酸酯的水解速率较低，多核苷酸的水解速率更低。在2'-氯-2'-脱氧尿苷系列中，除了阿拉伯核苷外，还形成了O2, 2'-环核苷。
相似文献
1
Hydrolysis in 2'-chloro-2'-deoxy nucleosides, -nucleotides and -polynucleotides to arabinose-derivatives.2'-氯-2'-脱氧核苷、核苷酸和多核苷酸水解生成阿拉伯糖衍生物。
Nucleic Acids Res. 1975 Oct;2(10):1987-94. doi: 10.1093/nar/2.10.1987.
2
Specificity of acid phosphatase from human prostate.
Acta Biochim Pol. 1971;18(3):249-60.
3
Studies on polynucleotides containing hybrid sequences. Synthesis of oligonucleotides containing thymidine, adenosine, and a single deoxyribonucleotidyl-(3'-5')-ribonucleotide linkage.含杂交序列的多核苷酸研究。含胸苷、腺苷及单个脱氧核糖核苷酸基 -（3'-5'）-核糖核苷酸连接的寡核苷酸的合成。
Biochemistry. 1973 Nov 20;12(24):4840-6. doi: 10.1021/bi00748a005.
4
Modification of polynucleotides by a fragment produced by enzymatic cleavage of S-(1, 2-dichlorovinyl)-L-cysteine.
Biochem Biophys Res Commun. 1973 Jul 2;53(1):172-81. doi: 10.1016/0006-291x(73)91416-2.
5
Interactions of polynucleotides and thier components. I. Dissociation constants of the bases and their derivatives.多核苷酸及其组分的相互作用。I. 碱基及其衍生物的解离常数。
Z Naturforsch B. 1968 Jan;23(1):25-30.
6
[Sequence determination of oligonucleotides].[寡核苷酸的序列测定]
Tanpakushitsu Kakusan Koso. 1972 Oct:Suppl:215-22.
7
A new chemical probe for single-stranded RNA.一种用于单链RNA的新型化学探针。
Biochem Biophys Res Commun. 1972 Oct 17;49(2):358-63. doi: 10.1016/0006-291x(72)90418-4.
8
Nucleoside and deoxynucleoside phosphorylation in formamide solutions.甲酰胺溶液中的核苷和脱氧核苷磷酸化作用
Orig Life. 1982 Jun;12(2):143-51. doi: 10.1007/BF00927141.
9
THE DEOXYRIBONUCLEASES OF ESCHERICHIA COLI. V. ON THE SPECIFICITY OF EXONUCLEASE I (PHOSPHODIESTERASE).大肠杆菌的脱氧核糖核酸酶。V. 关于核酸外切酶I（磷酸二酯酶）的特异性
J Biol Chem. 1964 Aug;239:2628-36.
10
Preparation of O'-alkyl derivatives of cytosine and uracil nucleosides.
Biochemistry. 1973 Jan 16;12(2):194-200. doi: 10.1021/bi00726a003.
本文引用的文献
1
Nucleosides. XXXIX. 2'-deoxy-2'-fluorocytidine, 1-beta-D-arabinofuranosyl-2-amino-1,4(2H)-4-iminopyrimidine, and related derivatives.
J Org Chem. 1967 May;32(5):1462-71. doi: 10.1021/jo01280a035.
2
Nucleotides. V. Purine ribonucleoside 2',3'-cyclic carbonates. Preparation and use for the synthesis of 5'-monosubstituted nucleosides.核苷酸。V. 嘌呤核糖核苷2',3'-环碳酸酯。5'-单取代核苷合成中的制备及应用
Biochemistry. 1966 Jun;5(6):2076-82. doi: 10.1021/bi00870a040.
3
Rapid ion-exchange chromatographic microanalysis of ultraviolet-absorbing materials and its application to nucleosides.紫外吸收物质的快速离子交换色谱微分析及其在核苷中的应用。
Anal Biochem. 1968 Oct 24;25(1):77-98. doi: 10.1016/0003-2697(68)90083-3.
4
Molecular and crystal structure of 2'-chloro-2'-deoxyuridine.2'-氯-2'-脱氧尿苷的分子结构与晶体结构
Biochim Biophys Acta. 1972 Jan 31;259(2):157-63. doi: 10.1016/0005-2787(72)90055-x.
5
Determination of the molecular conformation of beta-D-O2,2'-cyclouridine in aqueous solution by proton magnetic resonance spectroscopy.通过质子磁共振光谱法测定β-D-O2,2'-环尿苷在水溶液中的分子构象。
Biopolymers. 1973;12(10):2381-9. doi: 10.1002/bip.1973.360121016.
6
Conformational studies on pyrimidine 5'-monophosphates and 3',5'-diphosphates. Effect of the phosphate groups on the backbone conformation of polynucleotides.
Biopolymers. 1973;12(10):2261-77. doi: 10.1002/bip.1973.360121006.
7
Syn-anti effects on the spatial configuration of polynucleotide chains.对多核苷酸链空间构型的顺反效应。
Biopolymers. 1973;12(8):1787-814. doi: 10.1002/bip.1973.360120808.
8
The inhibition of avian myeloblastosis virus deoxyribonucleic acid polymerase by synthetic polynucleotides.合成多核苷酸对禽成髓细胞瘤病毒脱氧核糖核酸聚合酶的抑制作用。
Biochemistry. 1974 Apr 23;13(9):1987-93. doi: 10.1021/bi00706a032.
9
Polynucleotides containing 2'-chloro-2'-deoxyribose.含有2'-氯-2'-脱氧核糖的多核苷酸。
Biochemistry. 1972 Nov 7;11(23):4336-44. doi: 10.1021/bi00773a021.
10
The antiviral activity of certain thiophosphate and 2'-chloro substituted polynucleotide homopolymer duplexes.某些硫代磷酸酯和2'-氯取代的多核苷酸均聚物双链体的抗病毒活性。
Virology. 1972 May;48(2):537-45. doi: 10.1016/0042-6822(72)90064-5.
Zotero 插件