氟奋乃静对去甲肾上腺素与5-羟色胺相互作用的影响。
The influence of fluphenazine on the interaction of noradrenaline and serotonin.
作者信息
Janiec W, Piekarska T, Szczypior M, Mucha E
出版信息
Pol J Pharmacol Pharm. 1975 Oct;27(Suppl):95-8.
The neurotransmitter catecholamines control metabolism 5-HT in pineal gland by stimulating pineal serotonin-N-acetyltransferase (EC 2.3.1.5) activity [1, 2]. To prove the influence of FP on the metabolism 5-HT provoked by norepinephrine was tested. Rat pineal gland were incubated in media containing 5-HT- 14C or 5-HT- 14C and FP (1-10(-6)-1-10(-4) M). Norepinephrine (1-10(-6)-1-10(-4)M) was added at the start of the experiment. The level of cyclic 3',5'-AMP, activity of HIOMT and metabolites of 5-HT-14C was examined. The results have suggested that the FP inhibit the provoked by norepinephrine metabolism of 5-HT in the rat pineal gland by decrease the formation of c-3',5'-AMP.
神经递质儿茶酚胺通过刺激松果体血清素 -N - 乙酰转移酶（EC 2.3.1.5）的活性来控制松果体中5 - HT的代谢[1,2]。为了证明氟哌啶醇（FP）对去甲肾上腺素引发的5 - HT代谢的影响进行了测试。将大鼠松果体在含有5 - HT - 14C或5 - HT - 14C和氟哌啶醇（1×10⁻⁶ - 1×10⁻⁴M）的培养基中孵育。在实验开始时加入去甲肾上腺素（1×10⁻⁶ - 1×10⁻⁴M）。检测了环3',5'-AMP的水平、羟基吲哚 -O - 甲基转移酶（HIOMT）的活性以及5 - HT - 14C的代谢产物。结果表明，氟哌啶醇通过降低c - 3',5'-AMP的形成来抑制去甲肾上腺素引发的大鼠松果体中5 - HT的代谢。
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