褪黑素合成：3',5'-单磷酸腺苷和去甲肾上腺素刺激N-乙酰转移酶。
Melatonin synthesis: adenosine 3',5'-monophosphate and norepinephrine stimulate N-acetyltransferase.
作者信息
Klein D C, Berg G R, Weller J
出版信息
Science. 1970 May 22;168(3934):979-80. doi: 10.1126/science.168.3934.979.
PMID:4314985
Abstract
Treatment of cultured rat pineal glands with norepinephrine or dibutyryl adenosine 3',5'-monophosphate causes a six- to tenfold stimulation of N-acetyltransferase. This enzyme converts serotonin to N-acetylserotonin, the immediate precursor of melatonin. The increased synthesis of melatonin caused by norepinephrine treatment appears to be the result of stimulation of N-acetyltransferase by an adenosine 3',5'-monophosphate mechanism.
摘要
用去甲肾上腺素或二丁酰腺苷3',5'-单磷酸处理培养的大鼠松果体，可使N-乙酰转移酶受到6至10倍的刺激。该酶将血清素转化为N-乙酰血清素，即褪黑素的直接前体。去甲肾上腺素处理引起的褪黑素合成增加似乎是由腺苷3',5'-单磷酸机制刺激N-乙酰转移酶所致。
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