• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Heterogenic loss of BRCA in breast cancer: the "two-hit" hypothesis takes a hit.

作者信息

Meric-Bernstam Funda

出版信息

Ann Surg Oncol. 2007 Sep;14(9):2428-9. doi: 10.1245/s10434-007-9379-7. Epub 2007 Apr 4.

DOI:10.1245/s10434-007-9379-7
PMID:17406948
Abstract
摘要

相似文献

1
Heterogenic loss of BRCA in breast cancer: the "two-hit" hypothesis takes a hit.乳腺癌中BRCA的异质性缺失：“两次打击”假说受到冲击。
Ann Surg Oncol. 2007 Sep;14(9):2428-9. doi: 10.1245/s10434-007-9379-7. Epub 2007 Apr 4.
2
Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis.人类乳腺肿瘤发生过程中野生型BRCA等位基因的异质性缺失。
Ann Surg Oncol. 2007 Sep;14(9):2510-8. doi: 10.1245/s10434-007-9372-1. Epub 2007 Jun 29.
3
Selective loss of heterozygosity in multiple breast cancers from a carrier of mutations in both BRCA1 and BRCA2.一名同时携带BRCA1和BRCA2基因突变的患者的多例乳腺癌中出现杂合性缺失。
Cancer Res. 2002 May 15;62(10):2741-3.
4
One-hit effects and cancer.一击效应与癌症。
Cancer Prev Res (Phila). 2010 Jan;3(1):12-5. doi: 10.1158/1940-6207.CAPR-09-0249.
5
Skewed X chromosome inactivation and breast and ovarian cancer status: evidence for X-linked modifiers of BRCA1.X染色体失活偏倚与乳腺癌和卵巢癌状态：BRCA1的X连锁修饰因子的证据
J Natl Cancer Inst. 2008 Nov 5;100(21):1519-29. doi: 10.1093/jnci/djn345. Epub 2008 Oct 28.
6
Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ovarian cancer.散发性卵巢癌中控制BRCA1和BRCA2基因的表观遗传因素。
Cancer Res. 2002 Jul 15;62(14):4151-6.
7
Phenotypic expression of double heterozygosity for BRCA1 and BRCA2 germline mutations.BRCA1和BRCA2种系突变的双杂合子的表型表达。
J Med Genet. 2005 Mar;42(3):e20. doi: 10.1136/jmg.2004.027243.
8
Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility.乳腺癌和卵巢癌易感性的遗传风险评估及BRCA基因突变检测
Am Fam Physician. 2006 Nov 15;74(10):1759-60.
9
Methylation not a frequent "second hit" in tumors with germline BRCA mutations.胚系 BRCA 突变肿瘤中甲基化不是常见的“二次打击”。
Fam Cancer. 2009;8(4):339-46. doi: 10.1007/s10689-009-9240-1. Epub 2009 Apr 2.
10
"BRCAness" syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations.卵巢癌中的“BRCA样”综合征：一项病例对照研究，描述与BRCA1和BRCA2突变相关的上皮性卵巢癌患者的临床特征和预后。
J Clin Oncol. 2008 Dec 1;26(34):5530-6. doi: 10.1200/JCO.2008.16.1703. Epub 2008 Oct 27.

引用本文的文献

1
Characterization and functional analysis of BRCA1 and BRCA2 variants in a cohort of 100 unselected patients undergoing germline screening.对100例未经选择的进行种系筛查的患者队列中的BRCA1和BRCA2变异体进行特征分析和功能分析。
Transl Oncol. 2025 Sep;59:102471. doi: 10.1016/j.tranon.2025.102471. Epub 2025 Jul 14.
2
Association between homologous recombination deficiency and time to treatment failure to platinum-based chemotherapy for pancreatic cancer by using the C-CAT database.利用C-CAT数据库分析同源重组缺陷与胰腺癌铂类化疗治疗失败时间之间的关联。
J Gastroenterol. 2025 Feb;60(2):247-256. doi: 10.1007/s00535-024-02173-0. Epub 2024 Nov 21.
3
Blood molybdenum level as a marker of cancer risk on BRCA1 carriers.
血液钼水平作为BRCA1基因携带者癌症风险的标志物。
Hered Cancer Clin Pract. 2024 Sep 19;22(1):19. doi: 10.1186/s13053-024-00291-7.
4
Antioxidant Properties of Zinc and Copper-Blood Zinc-to Copper-Ratio as a Marker of Cancer Risk BRCA1 Mutation Carriers.锌和铜的抗氧化特性——血液锌铜比作为癌症风险BRCA1突变携带者的标志物
Antioxidants (Basel). 2024 Jul 14;13(7):841. doi: 10.3390/antiox13070841.
5
A BRCA1 Splice Site Variant Responsible for Familial Ovarian Cancer in a Han-Chinese Family.一个导致汉族家族性卵巢癌的 BRCA1 剪接位点变异。
Curr Med Sci. 2022 Jun;42(3):666-672. doi: 10.1007/s11596-022-2527-2. Epub 2022 Mar 15.
6
Identifying a c.5722_5723del mutation in a Han-Chinese family with breast cancer.鉴定一个汉族乳腺癌家系中的 c.5722_5723del 突变。
Biosci Rep. 2019 Apr 30;39(4). doi: 10.1042/BSR20182471.
7
In-Silico Integration Approach to Identify a Key miRNA Regulating a Gene Network in Aggressive Prostate Cancer.基于计算机的整合方法识别调控侵袭性前列腺癌基因网络的关键 miRNA。
Int J Mol Sci. 2018 Mar 19;19(3):910. doi: 10.3390/ijms19030910.
8
Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32,295 women.在一个包含32295名女性的国际样本中BRCA1和BRCA2基因有害突变的遗传情况。
Breast Cancer Res. 2016 Nov 11;18(1):112. doi: 10.1186/s13058-016-0768-3.
9
Molecular determination of the clonal relationships between multiple tumors in BRCA1/2-associated breast and/or ovarian cancer patients is clinically relevant.确定BRCA1/2相关乳腺癌和/或卵巢癌患者多种肿瘤之间的克隆关系具有临床意义。
Mod Pathol. 2017 Jan;30(1):15-25. doi: 10.1038/modpathol.2016.145. Epub 2016 Sep 9.
10
Integrating genetics and epigenetics in breast cancer: biological insights, experimental, computational methods and therapeutic potential.乳腺癌中遗传学与表观遗传学的整合：生物学见解、实验方法、计算方法及治疗潜力
BMC Syst Biol. 2015 Sep 21;9:62. doi: 10.1186/s12918-015-0211-x.