一击效应与癌症。
One-hit effects and cancer.
机构信息
Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan, Ann Arbor, 48109, USA.
出版信息
Cancer Prev Res (Phila). 2010 Jan;3(1):12-5. doi: 10.1158/1940-6207.CAPR-09-0249.
Abstract
This perspective on Bellacosa et al. (beginning on p. 48 in this issue of the journal) discusses the important biology of microscopically normal tissues in carriers of germ-line BRCA1 or BRCA2 mutations. The work of Bellacosa et al. is an important step toward discerning which pathways may be altered when one BRCA allele is inactivated.
摘要
这篇关于 Bellacosa 等人的观点（本期杂志第 48 页开始）讨论了携带胚系 BRCA1 或 BRCA2 突变的个体中显微镜下正常组织的重要生物学特性。Bellacosa 等人的工作是朝着辨别当一个 BRCA 等位基因失活时哪些途径可能发生改变迈出的重要一步。
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