Ziv I, Moskowitz R W, Kraise I, Adler J H, Maroudas A
Department of Orthopaedic Surgery, School of Medicine and Biomedical Sciences, State University of New York, Buffalo.
J Orthop Res. 1992 Mar;10(2):205-10. doi: 10.1002/jor.1100100207.
Hydration, fixed charge density, (FCD) and hydration under various osmotic pressures were compared in young, old, and young diabetic sand rats. This rat is a desert animal that may develop diabetes when fed a regular diet; it is also known to have radiographic and histologic evidence of intervertebral disc (IVD) disease. Forty-five rats and 180 IVD were used in this study; they were divided into three equal groups: young healthy, old healthy, and young diabetics. IVD, cancellous bone, and muscle were sampled from distal lumbar spines. The young diabetic rats (YD) were considerably heavier than the age-matched controls, had higher insulin and glucose levels, and all YD had cataracts. The discs of the young diabetic animals demonstrated decreased hydration, FCD and ability to resist compression under osmotic pressures as compared with the young and healthy discs and were more similar to the discs from old rats. The IVD is the most affected musculoskeletal connective tissue in sand rats with aging and diabetes. The aged and diabetic discs in the sand rat demonstrated changes similar to human changes with regard to lower hydration, FCD, and ability to resist osmotic pressure. Therefore, the sand rat may be a suitable animal model for studying the pathogenesis of disc degeneration.
对幼年、老年和幼年糖尿病沙鼠的水合作用、固定电荷密度（FCD）以及在不同渗透压下的水合作用进行了比较。这种沙鼠是一种沙漠动物，喂食常规饮食时可能会患糖尿病；已知其有椎间盘（IVD）疾病的影像学和组织学证据。本研究使用了45只沙鼠和180个椎间盘；它们被分为三组，每组数量相等：幼年健康组、老年健康组和幼年糖尿病组。从腰椎远端采集椎间盘、松质骨和肌肉样本。幼年糖尿病大鼠（YD）比年龄匹配的对照组重得多，胰岛素和葡萄糖水平更高，所有幼年糖尿病大鼠都患有白内障。与幼年健康椎间盘相比，幼年糖尿病动物的椎间盘在渗透压下的水合作用、FCD和抗压缩能力降低，并且更类似于老年大鼠的椎间盘。在沙鼠中，IVD是随着衰老和糖尿病而受影响最大的肌肉骨骼结缔组织。沙鼠的老年和糖尿病椎间盘在较低的水合作用、FCD和抗渗透压能力方面表现出与人类相似的变化。因此，沙鼠可能是研究椎间盘退变发病机制的合适动物模型。
