Alao John P
Department of Cell and Molecular Biology, Lundberg Laboratory, Gothenburg University, Gothenburg, Sweden.
Mol Cancer. 2007 Apr 2;6:24. doi: 10.1186/1476-4598-6-24.
Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the development and progression of cancer. Deregulated cyclin D1 degradation appears to be responsible for the increased levels of cyclin D1 in several cancers. Recent findings have identified novel mechanisms involved in the regulation of cyclin D1 stability. A number of therapeutic agents have been shown to induce cyclin D1 degradation. The therapeutic ablation of cyclin D1 may be useful for the prevention and treatment of cancer. In this review, current knowledge on the regulation of cyclin D1 degradation is discussed. Novel insights into cyclin D1 degradation are also discussed in the context of ablative therapy. A number of unresolved questions regarding the regulation of cellular cyclin D1 levels are also addressed.
细胞周期蛋白D1是细胞周期进程的重要调节因子，可作为转录共调节因子发挥作用。细胞周期蛋白D1的过表达与癌症的发生和发展有关。细胞周期蛋白D1降解失调似乎是几种癌症中细胞周期蛋白D1水平升高的原因。最近的研究发现了参与细胞周期蛋白D1稳定性调节的新机制。已证明多种治疗药物可诱导细胞周期蛋白D1降解。细胞周期蛋白D1的治疗性消除可能对癌症的预防和治疗有用。在这篇综述中，讨论了关于细胞周期蛋白D1降解调节的当前知识。在消融治疗的背景下，也讨论了对细胞周期蛋白D1降解的新见解。还解决了一些关于细胞周期蛋白D1水平调节的未解决问题。
