Hilterhaus Lutz, Liese Andreas
Institute for Technical Biocatalysis, Hamburg University of Technology, Denickestr. 15, 21073 Hamburg, Germany.
Adv Biochem Eng Biotechnol. 2007;105:133-73. doi: 10.1007/10_033.
This contribution illustrates the versatility of fundamental approaches in industrial biotransformations. The applicability of biotechnology in organic synthesis on an industrial scale is discussed, followed by an overview of historical development and future progress. This chapter depicts three different approaches for the use of biocatalysts in production processes: non-chiral synthesis, asymmetric synthesis, and racemic and dynamic resolution. Applications for whole cells and isolated enzymes as catalysts are introduced. Finally, critical but optimistic conclusions are given.
本论文阐述了工业生物转化基本方法的多功能性。讨论了生物技术在有机合成工业规模上的适用性，接着概述了其历史发展和未来进展。本章描述了在生产过程中使用生物催化剂的三种不同方法：非手性合成、不对称合成以及外消旋和动态拆分。介绍了全细胞和分离酶作为催化剂的应用。最后给出了批判性但乐观的结论。
