Tsen Shaw-Wei D, Paik Augustine H, Hung Chien-Fu, Wu T-C
Department of Pathology, John Hopkins School of Medicine, Baltimore, MD 21231, USA.
Expert Rev Vaccines. 2007 Apr;6(2):227-39. doi: 10.1586/14760584.6.2.227.
DNA vaccines represent a potentially promising approach for antigen-specific immunotherapy. Advances in our knowledge of the adaptive immune system have indicated that professional antigen-presenting cells, especially dendritic cells (DCs), play a key role in the generation of antigen-specific immune responses. Thus, the modification of the properties of DCs represents an important strategy for enhancing the potency of DNA vaccines. This review discusses strategies to increase the number of antigen-expressing DCs, enhance antigen expression, processing and presentation in DCs, promote the activation and function of DCs, and improve DC and T-cell interaction, in order to optimize DNA vaccine-elicited immune responses. Continuing progress in our understanding of DC and T-cell biology serves as a foundation for further improvement of DNA vaccine potency, which may lead to future clinical applications of DNA vaccines for the control of infectious diseases and malignancies.
DNA疫苗是抗原特异性免疫疗法中一种具有潜在前景的方法。我们对适应性免疫系统认识的进展表明，专职抗原呈递细胞，尤其是树突状细胞（DCs），在抗原特异性免疫反应的产生中起关键作用。因此，改变DCs的特性是增强DNA疫苗效力的重要策略。本综述讨论了增加表达抗原的DCs数量、增强DCs中抗原表达、加工和呈递、促进DCs的激活和功能以及改善DCs与T细胞相互作用的策略，以优化DNA疫苗引发的免疫反应。我们对DCs和T细胞生物学认识的不断进步为进一步提高DNA疫苗效力奠定了基础，这可能会使DNA疫苗在未来临床应用于控制传染病和恶性肿瘤。
