Laddy Dominick J, Weiner David B
Department of Pathology & Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Int Rev Immunol. 2006 May-Aug;25(3-4):99-123. doi: 10.1080/08830180600785827.
The field of DNA vaccine development began over 16 years ago with the observation that plasmid DNA could be injected into and expressed in vivo and drive adaptive immune responses. Since then, there has been great interest in developing this technology to create a new generation of vaccines with the ability to elicit both humoral and cellular immune responses from an inherently innocuous injection. However, DNA vaccines have yet to proceed past phase I/II clinical trials in humans--primarily due to a desire to induce more potent immune responses. This review will examine how DNA vaccines function to induce an immune response and how this information might be useful in future vaccine design.
DNA疫苗研发领域始于16年多以前，当时观察到质粒DNA可注射到体内并在体内表达，从而引发适应性免疫反应。从那时起，人们对开发这项技术以创造新一代疫苗产生了浓厚兴趣，这类疫苗能够通过本质上无害的注射引发体液免疫和细胞免疫反应。然而，DNA疫苗在人类中尚未进入超过I/II期临床试验阶段，主要原因是希望诱导更强有力的免疫反应。本综述将探讨DNA疫苗如何发挥作用以诱导免疫反应，以及这些信息在未来疫苗设计中可能如何有用。
