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[160例热性惊厥患儿的回顾性研究]

[Retrospective study of 160 children with febrile convulsions].

作者信息

Plöchl E, Laubichler W

机构信息

Kinderspital, Landeskrankenanstalten Salzburg.

出版信息

Klin Padiatr. 1992 Jan-Feb;204(1):16-20. doi: 10.1055/s-2007-1025316.

Abstract

In a retrospective study of 411 children with cerebral convulsions over a period of 4 years, 160 patients with febrile seizures were found. This group consisted of 94 boys and 66 girls. The main purpose of this study was to establish the age of the first convulsive fit in each child. Febrile convulsions started in the first half year, increased in the second half year and culminated in the second year of life. This age dependent appearance was explained with passive immunization by maternal antibodies so that febrile convulsions appear when these antibodies decrease. The first occurrence of febrile convulsions appeared on an average of 22.9 months, in children with recurrent febrile convulsions a little earlier with 18.2 months. The most interesting fact was that children with a family history of febrile seizures showed an even earlier occurrence of the first seizure with 14.5 months. This tendency of early incidence of febrile convulsion in the group with family history and in the group of recurrent febrile convulsions could be shown as statistically significant respectively nearly significant in comparing with the group of retarded patients. A peculiar tendency for febrile convulsions seems to be documented by recurrent seizures in the patient himself, but also by a history of febrile convulsions in other family members. Both facts may lead to a very early incidence of febrile convulsions.

摘要

在一项对411名患有脑惊厥的儿童进行的为期4年的回顾性研究中,发现160名患有热性惊厥。该组包括94名男孩和66名女孩。本研究的主要目的是确定每个孩子首次惊厥发作的年龄。热性惊厥始于上半年,下半年增加,并在生命的第二年达到高峰。这种年龄依赖性表现可以用母体抗体的被动免疫来解释,即当这些抗体减少时热性惊厥就会出现。首次热性惊厥的平均出现时间为22.9个月,复发性热性惊厥的儿童出现时间稍早,为18.2个月。最有趣的是,有热性惊厥家族史的儿童首次发作出现得更早,为14.5个月。与发育迟缓患者组相比,有家族史组和复发性热性惊厥组热性惊厥早期发病的这种趋势分别显示出统计学上的显著差异和近乎显著差异。热性惊厥的一种特殊趋势似乎不仅通过患者自身的复发性发作得到记录,而且通过其他家庭成员的热性惊厥病史也得到记录。这两个事实都可能导致热性惊厥的发病非常早。

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