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[复发性热性惊厥的危险因素]

[Risk factors in recurrent febrile seizures].

作者信息

Martín-Fernández J J, Moltó-Jordà J M, Villaverde R, Salmerón P, Prieto-Muñoz I, Fernández-Barreiro A

机构信息

Departamento de Neurología, Hospital Universitario Virgen de la Arrixaca, Murcia, España.

出版信息

Rev Neurol. 1996 Dec;24(136):1520-4.

PMID:9064166
Abstract

INTRODUCTION

Febrile convulsions are the most frequent type of seizures in children under 6 years old. They usually have a good prognosis. Only a few of these children will later suffer from non-febrile seizures. The low risk of non-febrile seizures and important side-effects of antiepileptic drugs have limited the use of continuous prophylaxis in children with recurrent febrile seizures.

OBJECTIVES

Our aim has been to identify the main factors that imply a higher risk for recurrent febrile convulsions and also to identify the frequency of antiepileptic prophylactic medication in our area.

MATERIAL AND METHODS

We have carried out a protocoled study in children which were sent consecutively and with no previous selection to a reference electroencephalography (EEG) outpatient unit in Murcia with the clinical diagnosis of febrile convulsions. Data included have been: sex, actual age and age at the time of the first seizure, total number of seizures, family and personal history of either febrile seizures or epilepsy, EEG findings, treatment and side-effects. Data collection was accomplished between September 1991 and June 1993. A total of 509 patients have been included.

RESULTS

A 34% of the children had suffered two or more seizures. Children with recurrent seizures were younger at onset (16.7 vs 21 months) and had more often family history of febrile seizures (40.6% vs 28%) and epilepsy (21.5% vs 12.5%). 60% of the children who had family history of febrile seizures of epilepsy and who suffered the first episode before the age of 16 months had recurrent febrile convulsions.

CONCLUSIONS

An age under 16 months at the moment of the first convulsion and the existence of family history of febrile seizures or epilepsy increase the risk of recurrent febrile seizures.

摘要

引言

热性惊厥是6岁以下儿童最常见的惊厥类型。它们通常预后良好。这些儿童中只有少数人后来会患无热惊厥。无热惊厥的低风险以及抗癫痫药物的重要副作用限制了对复发性热性惊厥儿童进行持续预防的应用。

目的

我们的目标是确定暗示复发性热性惊厥风险较高的主要因素,并确定我们地区抗癫痫预防性药物的使用频率。

材料与方法

我们对连续且未经事先挑选、临床诊断为热性惊厥的儿童进行了一项按方案的研究,这些儿童被送往穆尔西亚的一家参考脑电图(EEG)门诊单位。纳入的数据包括:性别、实际年龄和首次发作时的年龄、惊厥总数、热性惊厥或癫痫的家族史和个人史、脑电图结果、治疗及副作用。数据收集于1991年9月至1993年6月期间完成。共纳入509例患者。

结果

34%的儿童曾有两次或更多次惊厥发作。复发性惊厥的儿童发病时年龄更小(16.7个月对21个月),且热性惊厥家族史(40.6%对28%)和癫痫家族史(21.5%对12.5%)更常见。有热性惊厥或癫痫家族史且在16个月前首次发作的儿童中,60%有复发性热性惊厥。

结论

首次惊厥发作时年龄在16个月以下以及存在热性惊厥或癫痫家族史会增加复发性热性惊厥的风险。

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