Jacobs Muazzam, Togbe Dieudonnée, Fremond Cecile, Samarina Arina, Allie Nasiema, Botha Tania, Carlos Daniela, Parida Shreemanta K, Grivennikov Sergei, Nedospasov Sergei, Monteiro Analbery, Le Bert Marc, Quesniaux Valerie, Ryffel Bernhard
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Microbes Infect. 2007 Apr;9(5):623-8. doi: 10.1016/j.micinf.2007.02.002. Epub 2007 Feb 21.
Tumor necrosis factor (TNF) is critical and non-redundant to control Mycobacterium tuberculosis infection and cannot be replaced by other proinflammatory cytokines. Overproduction of TNF may cause immunopathology, while TNF neutralization reactivates latent and chronic, controlled infection, which is relevant for the use of neutralizing TNF therapies in patients with rheumatoid arthritis.
肿瘤坏死因子（TNF）对于控制结核分枝杆菌感染至关重要且无可替代，不能被其他促炎细胞因子所取代。TNF的过度产生可能会导致免疫病理反应，而TNF中和则会重新激活潜伏性和慢性的、已得到控制的感染，这与类风湿性关节炎患者使用TNF中和疗法有关。
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