线粒体细胞色素c氧化酶对亚铁细胞色素c的氧化作用。
Oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase.
作者信息
Errede B, Haight G P, Kamen M D
出版信息
Proc Natl Acad Sci U S A. 1976 Jan;73(1):113-7. doi: 10.1073/pnas.73.1.113.
Abstract
Attempts to rationalize the kinetics of cytochrome c oxidation catalyzed by solubilized mitochondrial cytochrome c oxidase (ferrocytochrome c:oxygen oxidoreductase, EC 1.9.3.1) have been based on assumptions of productive complex formation (Michaelis-Menten approach). However, the range of substrate concentrations used has not, in general, been sufficient to establish a general rate equation. Data adequate to derive such a rate expression are presented, as well as a method for estimation of constants which appear in the rate law deduced and reported herein. It is shown that either of two types of mechanisms, one assuming productive complex formation, as opposed to the other postulating dead-end complex formation, accurately predict the rate equation as deduced from experiment.
摘要
为使溶解的线粒体细胞色素c氧化酶（亚铁细胞色素c：氧氧化还原酶，EC 1.9.3.1）催化的细胞色素c氧化动力学合理化，人们一直基于生成性复合物形成的假设（米氏方法）。然而，一般而言，所使用的底物浓度范围不足以建立一个通用的速率方程。本文给出了足以推导这种速率表达式的数据，以及一种估算本文推导并报道的速率定律中出现的常数的方法。结果表明，两种机制中的任何一种，一种假设生成性复合物形成，另一种假设生成无活性复合物形成，都能准确预测从实验推导得出的速率方程。
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