Matsuo Tomohide, Cerruto Noya Claudia A, Taylor DeMar, Fujisaki Kozo
Division of Tropical Diseases and Parasitology, Department of Infectious Diseases, Kyorin University School of Medicine, Japan.
J Vet Med Sci. 2007 Mar;69(3):317-20. doi: 10.1292/jvms.69.317.
Growth factors, Platelet Derived Growth Factor (PDGF) and Transforming Growth Factor (TGF)-beta, were demonstrated in vertebrate and invertebrate immmunocytes. It is generally known that the growth factors are important in various biological processes, such as the regulation of cell differentiation, development and wound healing. In the present study, the presence of TGF-beta1 and PDGF-receptor-alpha in plasmatocytes and PDGF-AB in granulocytes of a soft tick, Ornithodoros moubata, was confirmed immunohistochemically. The tick midgut might be damaged by intracellular digestion and penetration of protozoa. Therefore, it is considered that PDGF from granulocytes may affect the PDGF-receptor-alpha in plasmatocytes and TGF-beta from plasmatocytes may function to repair the midgut. The results obtained here add to the elucidation of the functions of tick hemocytes.
生长因子，血小板衍生生长因子（PDGF）和转化生长因子（TGF）-β，已在脊椎动物和无脊椎动物的免疫细胞中得到证实。众所周知，生长因子在各种生物过程中都很重要，例如细胞分化、发育和伤口愈合的调节。在本研究中，通过免疫组织化学证实了软蜱钝缘蜱的浆细胞中存在TGF-β1和PDGF受体-α，粒细胞中存在PDGF-AB。蜱的中肠可能会受到原生动物细胞内消化和穿透的损害。因此，认为粒细胞中的PDGF可能会影响浆细胞中的PDGF受体-α，而浆细胞中的TGF-β可能起到修复中肠的作用。此处获得的结果有助于阐明蜱血细胞的功能。
