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PDGF and TGF-beta induce cell shape changes in invertebrate immunocytes via specific cell surface receptors.

作者信息

Kletsas D, Sassi D, Franchini A, Ottaviani E

机构信息

Institute of Biology, National Center for Scientific Research Demokritos, Athens, Greece.

出版信息

Eur J Cell Biol. 1998 Apr;75(4):362-6. doi: 10.1016/s0171-9335(98)80069-1.

DOI:10.1016/s0171-9335(98)80069-1
PMID:9628322
Abstract

The presence of PDGF receptor-alpha- and -beta- and TGF-beta-receptor (type II)-like molecules on the plasma membranes of the immunocytes of the mollusc Mytilus galloprovincialis was demonstrated by an immunocytochemical procedure. Furthermore, the present study provides evidence that PDGF-AB and TGF-beta1 provoke cell shape changes in immunocytes via interactions with the respective receptors and that these extracellular signals are transduced along the phosphoinositide signaling pathway.

摘要

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