牛淀粉样变性病中的血清淀粉样蛋白A和触珠蛋白水平

Serum amyloid A and haptoglobin levels in bovine amyloidosis.

作者信息

Takahashi Eiji, Uzuka Yuuji, Tanabe Sigeyuki, Satoh Motoyoshi, Furuoka Hidefumi

机构信息

Department of Veterinary Clinical Science, United Graduate School of Veterinary Science, Gifu University, Japan.

出版信息

J Vet Med Sci. 2007 Mar;69(3):321-3. doi: 10.1292/jvms.69.321.

DOI:10.1292/jvms.69.321

PMID:17409654

Abstract

Serum amyloid A (SAA) and haptoglobin (Hp) levels were determined in 25 cows suffering from amyloidosis. SAA levels in cows with amyloidosis ranged between < 0.3 and 225.8 microg/ml, with a median level of 105.1 microg/ml, and Hp levels ranged between < 20 and 1860 microg/ml, with a median level of 950 microg/ml. These levels were significantly higher than the levels observed in healthy cows (SAA levels ranged from < 0.3 to 13.5 microg/ml, with median of 1.4 microg/ml, and Hp levels were undetectable in all cases), but were not significantly different from the levels observed in control cows with chronic inflammation. There was a significant correlation between SAA and Hp levels in cows with chronic inflammation , but not in cows with amyloidosis. It was concluded that the serum SAA levels in cows with amyloidosis might be changed by some factor other than inflammation.

摘要

对25头患有淀粉样变的奶牛测定了血清淀粉样蛋白A（SAA）和触珠蛋白（Hp）水平。患有淀粉样变的奶牛的SAA水平在<0.3至225.8微克/毫升之间，中位数水平为105.1微克/毫升，Hp水平在<20至1860微克/毫升之间，中位数水平为950微克/毫升。这些水平显著高于健康奶牛中观察到的水平（SAA水平范围为<0.3至13.5微克/毫升，中位数为1.4微克/毫升，且所有病例中均未检测到Hp水平），但与患有慢性炎症的对照奶牛中观察到的水平无显著差异。在患有慢性炎症的奶牛中，SAA和Hp水平之间存在显著相关性，但在患有淀粉样变的奶牛中则不存在。得出的结论是，患有淀粉样变的奶牛的血清SAA水平可能受炎症以外的某些因素影响而发生变化。