Bartlett Susan L, Lamberski Nadine, Arheart Kristopher L, Cray Carolyn
Wildlife Conservation Society, Zoological Health Program, Bronx, NY, United States.
San Diego Zoo Safari Park, Escondido, CA, United States.
Front Vet Sci. 2021 Apr 28;8:646500. doi: 10.3389/fvets.2021.646500. eCollection 2021.
Serum samples collected from 37 clinically normal bongo () and 13 abnormal bongo were tested using assays for acute-phase proteins (APPs) and by protein electrophoresis. Abnormal bongo samples ( = 27) had significantly higher levels of fibrinogen (FIB) ( < 0.001) and trending but not significantly increased haptoglobin (HP) ( = 0.07) vs. samples from normal bongo ( = 37). There were no significant differences in values for total white blood cell counts or for any of the fractions determined by protein electrophoresis. Clinically normal female bongo ( = 19) had significantly lower levels of FIB than normal males ( = 18) ( = 0.014), and this observation was also made with samples from the clinically abnormal group ( = 0.004). Many weak to moderate significant correlations were observed with increasing age, including increased globulins, FIB, and HP and decreased albumin-to-globulin (A/G) ratio and albumin. In clinical cases reviewed in this study, mild HP changes categorized this reactant as a minor APP, which contrasts with the major APP classification of HP in the related species of the cow. The preliminary data indicate that the quantitation of these APPs may offer value in assessing inflammation in this species, but additional studies are needed.
从37只临床正常的邦戈羚羊和13只异常邦戈羚羊采集血清样本，使用急性期蛋白（APPs）检测方法和蛋白质电泳进行检测。与正常邦戈羚羊（n = 37）的样本相比，异常邦戈羚羊样本（n = 27）的纤维蛋白原（FIB）水平显著更高（P < 0.001），触珠蛋白（HP）有上升趋势但无显著升高（P = 0.07）。白细胞总数或蛋白质电泳测定的任何组分的值均无显著差异。临床正常的雌性邦戈羚羊（n = 19）的FIB水平显著低于正常雄性（n = 18）（P = 0.014），临床异常组的样本也有此现象（P = 0.004）。随着年龄增长观察到许多弱至中度的显著相关性，包括球蛋白、FIB和HP升高，白蛋白/球蛋白（A/G）比值和白蛋白降低。在本研究回顾的临床病例中，轻度的HP变化将该反应物归类为次要APP，这与牛相关物种中HP的主要APP分类形成对比。初步数据表明，这些APPs的定量分析可能对评估该物种的炎症有价值，但还需要更多研究。
